Structural Formula Vector Image
Title: Etonogestrel
CAS Registry Number: 54048-10-1
CAS Name: (17a)-13-Ethyl-17-hydroxy-11-methylene-18,19-dinorpregn-4-en-20-yn-3-one
Additional Names: 17-ethynyl-17b-hydroxy-18-methyl-11-methyleneestr-4-en-3-one; 3-ketodesogestrel; 3-oxodesogestrel
Manufacturers' Codes: Org-3236
Trademarks: Implanon (Organon)
Molecular Formula: C22H28O2
Molecular Weight: 324.46
Percent Composition: C 81.44%, H 8.70%, O 9.86%
Literature References: Biologically active metabolite of desogestrel, q.v.. Prepn: H. Hofmeister et al., EP 51762; eidem, US 4371529 (1982, 1983 both to Schering AG); H. Gao et al., Steroids 62, 398 (1997). Series of articles on clinical experience: Contraception 58, Suppl. 1, 75S-115S (1998). Clinical safety and efficacy: H. B. Croxatto et al., Hum. Reprod. 14, 976 (1999). Review of clinical studies: J. E. Edwards, A. Moore, Br. J. Fam. Plann. 24, 3-16 (1999).
Properties: mp 199-201°. [a]D +87.6°.
Melting point: mp 199-201°
Optical Rotation: [a]D +87.6°
Therap-Cat: Progestogen; implantable contraceptive.
Keywords: Contraceptive (Implantable); Progestogen.

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