Dextroamphetamine
Structural Formula Vector Image
Title: Dextroamphetamine
CAS Registry Number: 51-64-9
CAS Name: (aS)-a-Methylbenzeneethanamine
Additional Names: (+)-a-methylphenethylamine; d-amphetamine; (S)-1-phenyl-2-aminopropane; d-b-phenylisopropylamine; dexamphetamine
Molecular Formula: C9H13N
Molecular Weight: 135.21
Percent Composition: C 79.95%, H 9.69%, N 10.36%
Literature References: Prepn by resolution of amphetamine: Temmler, GB 508757 (1939); Nabenhauer, US 2276508 (1942 to SK&F); Magidson, Garkusha, J. Gen. Chem. USSR 11, 339 (1941); from D-phenylalanine: D. B. Repke et al., J. Pharm. Sci. 67, 1167 (1978). Toxicity data: E. J. Warawa et al., J. Med. Chem. 18, 71 (1975). GC-MS determn in urine: V. A Tetlow, J. Merrill, Ann. Clin. Biochem. 33, 50 (1996). Review of pharmacology: S. J. Chee, Neurosci. Biobehav. Rev. 16, 481-496 (1992).
 
Derivative Type: Sulfate
CAS Registry Number: 51-63-8
Trademarks: Dexamin (Streuli); Dexedrine (GSK); Dextrostat (Shire)
Properties: White, odorless, crystalline powder with bitter taste. mp >300°. [a]D20 +21.8° (c = 2). Freely sol in water (about 1:10); slightly sol in alcohol (about 1:800). Insol in ether. pH 5% aq soln: 5.0 to 6.0. LD50 orally in mice: 10 mg/kg (Warawa).
Melting point: mp >300°
Optical Rotation: [a]D20 +21.8° (c = 2)
Toxicity data: LD50 orally in mice: 10 mg/kg (Warawa)
 
Derivative Type: Tannate
CAS Registry Number: 1407-85-8
Additional Names: Tanphetamin
Trademarks: Synatan (Ferring)
Literature References: Prepn: Cavallito, US 2950309 (1960 to Irwin, Neisler and Co.).
 
NOTE: This is a controlled substance (stimulant): 21 CFR, 1308.12.
Therap-Cat: CNS stimulant; anorexic.
Keywords: Anorexic; CNS Stimulant.

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