Cloconazole
Structural Formula Vector Image
Title: Cloconazole
CAS Registry Number: 77175-51-0
CAS Name: 1-[1-[2-[(3-Chlorophenyl)methoxy]phenyl]ethenyl]-1H-imidazole
Additional Names: 1-[1-[2-[(3-chlorobenzyl)oxy]phenyl]vinyl]-1H-imidazole; croconazole
Molecular Formula: C18H15ClN2O
Molecular Weight: 310.78
Percent Composition: C 69.56%, H 4.86%, Cl 11.41%, N 9.01%, O 5.15%
Literature References: Antimycotic vinylimidazole. Prepn and antifungal properties: M. Ogata et al., BE 883665; eidem, US 4328348 (1980, 1982 both to Shionogi); eidem, J. Med. Chem. 26, 768 (1983). Pharmacology: K. Yamamoto et al., Oyo Yakuri 27, 533 (1984), C.A. 101, 16881c (1984). Series of articles on metabolism in rats and rabbits: K. Mizojiri et al., Iyakuhin Kenkyu 16, 177-206 (1985), C.A. 103, 47788y; 47789z; 47790t (1985). Mechanism of action study: T. Hiratani, H. Yamaguchi, Chemotherapy (Tokyo) 33, 579 (1985).
Properties: mp 72-73°. Sol in ethyl acetate.
Melting point: mp 72-73°
 
Derivative Type: Monohydrochloride
CAS Registry Number: 77174-66-4
Manufacturers' Codes: 710674-S
Trademarks: Pilzcin (Shionogi)
Molecular Formula: C18H15ClN2O.HCl
Molecular Weight: 347.24
Percent Composition: C 62.26%, H 4.64%, Cl 20.42%, N 8.07%, O 4.61%
Properties: Crystals from ethyl acetate + acetonitrile, mp 148.5-150°. LD50 in rats (mg/kg): 7000 s.c.; 2500 orally (Ogata, 1983).
Melting point: mp 148.5-150°
Toxicity data: LD50 in rats (mg/kg): 7000 s.c.; 2500 orally (Ogata, 1983)
 
Therap-Cat: Antifungal (topical).
Keywords: Antifungal (Synthetic); Imidazoles.

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