Structural Formula Vector Image
Title: Clanobutin
CAS Registry Number: 30544-61-7
CAS Name: 4-[(4-Chlorobenzoyl)(4-methoxyphenyl)amino]butanoic acid
Additional Names: 4-[p-chloro-N-(p-methoxyphenyl)benzamido]butyric acid; N-(p-chlorobenzoyl)-g-(p-anisidino)butyric acid
Trademarks: Bykahepar (Byk Gulden)
Molecular Formula: C18H18ClNO4
Molecular Weight: 347.79
Percent Composition: C 62.16%, H 5.22%, Cl 10.19%, N 4.03%, O 18.40%
Literature References: Prepn: K. Klemm et al., DE 1917036; eidem, US 3780095 (1971, 1973 both to Byk-Gulden). Series of articles on synthesis, physical and pharmacological properties: Arzneim.-Forsch. 29, 1-15 (1979). In vitro biochemical study: H. Wolf et al., Biochem. Pharmacol. 29, 1649 (1980). Effect on bile excretion in rats, dogs: P. Berchtold et al., Arzneim.-Forsch. 30, 1878 (1980).
Properties: Cryst from ethyl acetate, mp 115-116°. pKa 5.04. Soly in water at 37°: 4.02´10-2 mol/l at pH 7. LD50 in rats (mg/kg): >2000 orally; 570 i.v. (Klemm).
Melting point: mp 115-116°
pKa: pKa 5.04
Toxicity data: LD50 in rats (mg/kg): >2000 orally; 570 i.v. (Klemm)
Therap-Cat: Choleretic.
Therap-Cat-Vet: Choleretic; in treatment of piroplasmosis and anaplasmosis.
Keywords: Choleretic.

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