Structural Formula Vector Image
Title: Bromhexine
CAS Registry Number: 3572-43-8
CAS Name: 2-Amino-3,5-dibromo-N-cyclohexyl-N-methylbenzenemethanamine
Additional Names: 3,5-dibromo-Na-cyclohexyl-Na-methyltoluene-a,2-diamine; N-cyclohexyl-N-methyl-2-(2-amino-3,5-dibromo)benzylammonium; N-(2-amino-3,5-dibromobenzyl)-N-methylcyclohexylammonium
Molecular Formula: C14H20Br2N2
Molecular Weight: 376.13
Percent Composition: C 44.71%, H 5.36%, Br 42.49%, N 7.45%
Literature References: Prepn: Keck, Ann. 662, 171 (1963); K. Thomae, BE 625022 (1963), C.A. 61, 5564 (1964). Pharmacology: R. Engelhorn, S. P├╝schmann, Arzneim.-Forsch. 13, 474 (1963). Metabolism: R. Jauch et al., ibid. 25, 1954 (1975). Toxicity: Boyd, Sheppard, Arch. Int. Pharmacodyn. Ther. 163, 284 (1966).
Properties: Crystals from abs ethanol, dec 237.5-238┬░. One gram dissolves in 250 ml of water or 10% ethanol. Approx LD50 orally in rabbits: >10 g/kg (Boyd, Sheppard).
Toxicity data: Approx LD50 orally in rabbits: >10 g/kg (Boyd, Sheppard)
Derivative Type: Hydrochloride
CAS Registry Number: 611-75-6
Manufacturers' Codes: NA-274
Trademarks: Auxit (BMS); Bisolvon (Thomae); Ophtosol (Winzer); Quentan (Boehringer, Ing.)
Molecular Formula: C14H20Br2N2.HCl
Molecular Weight: 412.59
Percent Composition: C 40.75%, H 5.13%, Br 38.73%, N 6.79%, Cl 8.59%
Therap-Cat: Expectorant; mucolytic.
Therap-Cat-Vet: Expectorant.
Keywords: Expectorant; Mucolytic.

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