Structural Formula Vector Image
Title: Beclobrate
CAS Registry Number: 55937-99-0
CAS Name: 2-[4-[(4-Chlorophenyl)methyl]phenoxy]-2-methylbutanoic acid ethyl ester
Additional Names: (±)-2-methyl-2-[p-(p¢-chlorobenzyl)phenoxy]butyric acid ethyl ester; ethyl (±)-2-[[a-(p-chlorophenyl)-p-tolyl]oxy]-2-methylbutyrate
Manufacturers' Codes: Sgd-24774
Trademarks: Beclipur (Siegfried); Turec (Novartis)
Molecular Formula: C20H23ClO3
Molecular Weight: 346.85
Percent Composition: C 69.26%, H 6.68%, Cl 10.22%, O 13.84%
Literature References: Diphenylmethane derivative. Prepn: K. Thiele et al., DE 2461069; eidem, US 4483999 (1975, 1984 both to Siegfried); eidem, Arzneim.-Forsch. 29, 711 (1979). Preliminary clinical trial in hyperlipidemia: C. Najemnik et al., ibid. 31, 2168 (1981). Series of articles on pharmacology: ibid. 33, 1464-1472 (1983). Metabolism: W. Roth et al., ibid. 35, 244 (1985). Pharmacokinetics: I. Gikalov, U. Ifflaender, ibid. 37, 1065 (1987).
Properties: Oil, bp0.01-0.1 200-204°. LD50 orally in mice: 8000 mg/kg (Thiele, 1979).
Boiling point: bp0.01-0.1 200-204°
Toxicity data: LD50 orally in mice: 8000 mg/kg (Thiele, 1979)
Therap-Cat: Antilipemic.
Keywords: Antihyperlipoproteinemic; Fibrates.
Status: This monograph has been retired and is no longer subject to revision or update.

Other Monographs:
Salicyl AlcoholIoversolBeryllium Potassium Sulfate3,4-Dichloroaniline
BrodifacoumLysidineFactor IXThreonine
FantofaroneOil of FleabaneImipramine N-OxidePotassium Phosphate, Tribasic
SabadillaPalonosetronDichlofenthionMethanesulfonic Acid
©2006-2023 DrugFuture->Chemical Index Database