Dichlorophenarsine Hydrochloride
Structural Formula Vector Image
Title: Dichlorophenarsine Hydrochloride
CAS Registry Number: 536-29-8
CAS Name: (3-Amino-4-hydroxyphenyl)arsonous dichloride monohydrochloride
Additional Names: (3-amino-4-hydroxyphenyl)dichloroarsine hydrochloride
Manufacturers' Codes: RP-2591
Trademarks: Arseclor; Chlorarsen; Chlorarsol; Clorarsen; Dichloro-Mapharsen; Filarsen; Fontarsol; Halarsol
Molecular Formula: C6H7AsCl3NO
Molecular Weight: 290.41
Percent Composition: C 24.81%, H 2.43%, As 25.80%, Cl 36.62%, N 4.82%, O 5.51%
Literature References: Prepd by the action of arsenic trichloride on o-aminophenol, or from the corresp arsine oxide and an excess of HCl: DE 281101; from arsphenamine by treatment with mercuric chloride and HCl gas: Binz, Bauer, Z. Angew. Chem. 34, 261 (1921). Toxicity: Beck, Proc. Soc. Exp. Biol. Med. 78, 392 (1951).
Properties: White hygroscopic powder. mp 200°. Readily sol in water yielding a soln of oxophenarsine. Usually marketed mixed with 3.33 times its weight of sodium citrate-carbonate as buffer to make a soln of pH 6.2 isotonic with human blood. LD50 i.p. in mice: 41 mg/kg (Beck).
Melting point: mp 200°
Toxicity data: LD50 i.p. in mice: 41 mg/kg (Beck)
Therap-Cat: Formerly as antisyphilitic.
Therap-Cat-Vet: Has been used as a filaricide.
Keywords: Antisyphilitic.
Status: This monograph has been retired and is no longer subject to revision or update.

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