Structural Formula Vector Image
Title: Azosemide
CAS Registry Number: 27589-33-9
CAS Name: 2-Chloro-5-(1H-tetrazol-5-yl)-4-[(2-thienylmethyl)amino]benzenesulfonamide
Additional Names: 2-chloro-5-(2H-tetrazol-5-yl)-N4-2-thenylsulfanilamide; 5-(4¢-chloro-2¢-thenylamino-5¢-sulfamoylphenyl)tetrazole
Manufacturers' Codes: Ple-1053
Trademarks: Diart (Boehringer, Mann.); Luret (Sanofi Winthrop)
Molecular Formula: C12H11ClN6O2S2
Molecular Weight: 370.84
Percent Composition: C 38.87%, H 2.99%, Cl 9.56%, N 22.66%, O 8.63%, S 17.29%
Literature References: Prepn: A. Popelak et al., DE 1815922; eidem, US 3665002 (1968, 1972 both to Boehringer, Mann.). Separation and analysis in blood and urine by HPLC: R. Seiwell, C. Brater, J. Chromatogr. 182, 257 (1980). Sites of action: C. Brater, Clin. Pharmacol. Ther. 25, 428 (1979). Clinical and pharmacological studies: F. Krueck et al., Eur. J. Clin. Pharmacol. 14, 153 (1978). Diuretic effect in animals: J. Greven, O. Heidenreich, Arzneim.-Forsch. 31, 346, 350 (1981).
Properties: Crystals, mp 218-221°.
Melting point: mp 218-221°
Therap-Cat: Diuretic.
Keywords: Diuretic; Sulfonamide Derivatives.

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