Antimycin A1
Structural Formula Vector Image
Title: Antimycin A1
CAS Registry Number: 642-15-9
Additional Names: 3-Methylbutanoic acid 3-[[3-(formylamino)-2-hydroxybenzoyl]amino]-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl ester; isovaleric acid 8-ester with 3-formamido-N-(7-hexyl-8-hydroxy-4,9-dimethyl-2,6-dioxo-1,5-dioxonan-3-yl)salicylamide
Molecular Formula: C28H40N2O9
Molecular Weight: 548.63
Percent Composition: C 61.30%, H 7.35%, N 5.11%, O 26.25%
Literature References: Antibiotic substance produced by Streptomyces spp. Isoln: Dunshee et al., J. Am. Chem. Soc. 71, 2436 (1949); Lockwood et al., Phytopathology 44, 438 (1954); US 2657170 (1953 to Wisconsin Alumni Res. Found.). Structure: van Tamelen et al., J. Am. Chem. Soc. 83, 1639 (1961); Birch et al., J. Chem. Soc. 1961, 889. Absolute config.: Kinoshita et al., J. Antibiot. 25, 373 (1972).
Properties: Crystals from ethyl acetate + Skellysolve B, mp 149-150°. [a]D26 +76° (c = 1 in chloroform). uv max (alc): 226, 320 nm (log e 4.54, 3.68). Freely sol in alc, ether, acetone, chloroform. Very slightly sol in petr ether, benzene, carbon tetrachloride. Practically insol in water and in 5% aq solns of hydrochloric acid, sodium carbonate and sodium bicarbonate. In aq sodium hydroxide a milky suspension is formed. This clears on warming, but all potency is lost.
Melting point: mp 149-150°
Optical Rotation: [a]D26 +76° (c = 1 in chloroform)
Absorption maximum: uv max (alc): 226, 320 nm (log e 4.54, 3.68)
Use: Experimentally as fungicide, insecticide, miticide.

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