Acetrizoate Sodium
Structural Formula Vector Image
Title: Acetrizoate Sodium
CAS Registry Number: 129-63-5
CAS Name: 3-(Acetylamino)-2,4,6-triiodobenzoic acid sodium salt
Additional Names: 3-acetamido-2,4,6-triiodobenzoic acid sodium salt; acetrizoic acid sodium salt
Trademarks: Cystokon (Mallinckrodt); Diaginol (M & B); Pyelokon-R (Mallinckrodt); Thixokon (Mallinckrodt); Urokon Sodium (Mallinckrodt)
Molecular Formula: C9H5I3NNaO3
Molecular Weight: 578.84
Percent Composition: C 18.67%, H 0.87%, I 65.77%, N 2.42%, Na 3.97%, O 8.29%
Literature References: Prepn: Wallingford et al., J. Am. Chem. Soc. 74, 4365 (1952); Wallingford, J. Am. Pharm. Assoc. Sci. Ed. 42, 721 (1953). Toxicity data: J. O. Hoppe et al., J. Pharmacol. Exp. Ther. 116, 394 (1956).
Properties: Not isolated from soln. Marketed as a sterile 30% aq soln, pH between 4.8 and 5.2. The free acid is a white powder, decompn 278-283°. Sol in alcohol. Solubility in water at 25°: 94.2 g/100 ml. Very slightly sol in chloroform. Practically insol in benzene. LD50 in rabbits, cats, dogs (mg/kg): 5200, 5600, 6300 i.v. (Hoppe).
Toxicity data: LD50 in rabbits, cats, dogs (mg/kg): 5200, 5600, 6300 i.v. (Hoppe)
Derivative Type: Mixture with meglumine acetrizoate
Trademarks: Opacoron (Cilag)
Therap-Cat: Diagnostic aid (radiopaque medium).
Keywords: Diagnostic Aid (Radiopaque Medium).

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