Butyl Alcohol
» Butyl Alcohol is n-butyl alcohol.
Packaging and storage— Preserve in tight containers, and prevent exposure to excessive heat.
Specific gravity 841: between 0.807 and 0.809.
Distilling range, Method II 721 It distills within a range of 1.5, including 117.7.
Acidity— Titrate 74 mL (60 g) of it with 0.020 N alcoholic potassium hydroxide, using phenolphthalein TS as the indicator, until a pink color persists for not less than 15 seconds: not more than 2.5 mL is consumed.
Water, Method I 921: not more than 0.1%.
Limit of nonvolatile residue— Evaporate 100 mL in a tared porcelain dish on a steam bath, and dry at 105 for 30 minutes: the weight of the residue does not exceed 4 mg (0.004%).
Aldehydes— To 10 mL of silver-ammonia-nitrate TS in a test tube add 10 mL of Butyl Alcohol, and mix. Allow the mixture to stand in a dark place for 30 minutes: no color is produced, although a slight precipitate may form at the interface of the two layers.
Butyl ether— Under typical conditions, the gas chromatograph (see Chromatography 621) is equipped with a thermal conductivity detector, and contains a 6-mm × 2-m stainless steel column packed with 25% liquid phase G29 3,3¢-thiodipropionitrile on 30- to 40-mesh support S1C, maintained at a temperature of 85. Helium is used as the carrier gas at a flow rate of about 75 mL per minute. Inject a suitable volume (about 10 µL) of Butyl Alcohol, and measure the peak responses. Using these conditions, retention times are approximately 6.0 minutes for butyl ether; 12.0 minutes for 2-butanol; 17.0 minutes for water; 18.0 minutes for isobutyl alcohol; and 25.0 minutes for butyl alcohol: the response due to butyl ether is not more than 0.2% of the sum of all of the responses.
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Monograph Robert H. Lafaver, B.A.
(EM105) Excipient Monographs 1
USP32–NF27 Page 1177
Chromatographic Column—
Chromatographic columns text is not derived from, and not part of, USP 32 or NF 27.