SOLUBILITIES
Approximate Solubilities of USP and NF Articles
Name and Volume, in mL, of Solvent
Solute (1 g) Water Boiling
Water		 Alcohol Chloroform Ether Other
Acenocoumarol 67,000 280 130 1800
Acetaminophen 20 10 1 N sodium hydroxide, 15
Acetohexamide 230 210
Acetylcysteine 5 4
Acetyldigitoxin 6100 62.5 12 >10,000
Ammonium Alum 7 0.5
Aluminum Chloride 0.9 4
Aluminum Sulfate 1
Amantadine Hydrochloride 2.5 5.1 18 polyethylene glycol 400, 70
Amaranth 15
Aminocaproic Acid 3 methanol, 450
Aminohippuric Acid 45 50 3 N hydrochloric acid, 5
Aminosalicylate Sodium 2
Ammonium Carbonate 4
Amodiaquine Hydrochloride 25 78 >10,000 >10,000 benzene, 10,000
Anethole1 2
Anileridine >10,000 2 1
Anileridine Hydrochloride 5 80 >10,000 >10,000
Antimony Potassium Tartrate 12 3 glycerin, 15
Apomorphine Hydrochloride 50 50 water at 80, 20
Apraclonidine Hydrochloride 34 74 >10,000 methanol, 13; ethyl acetate, >10,000; hexanes, >10,000
Ascorbic Acid 3 40
Ascorbyl Palmitate >1000 125 >1000 >1000
Aspirin 300 5 17 10 to 15
Atropine 460 2 1 25 water at 80, 90
Atropine Sulfate 0.5 2.5 5 glycerin, 2.5
Bendroflumethiazide 23 200
Benoxinate Hydrochloride 0.8 2.6 2.5 >10,000
Benzalkonium Chloride (anhydrous) 100 benzene, 6
Gamma Benzene Hexachloride 3.5 40 dehydrated alcohol, 20
Benzethonium Chloride <1 <1 <1 6000
Benzocaine 2500 5 2 4 almond oil or olive oil, 30–50
Benzoic Acid 300 3 5 3
Benzonatate <1 <1 <1 <1
Betadex 54
Betamethasone 5300 65 325 warm alcohol, 15; methanol, 3
Betamethasone Acetate 2000 9 16
Betamethasone Sodium Phosphate 2 470 >10,000 >10,000
Betamethasone Valerate 10,000 16 <10 400
Bisacodyl >10,000 210 2.5 275
Boric Acid 18 4 18 boiling alcohol, 6; glycerin, 4
Bromodiphenhydramine Hydrochloride <1 2 2 3500 isopropyl alcohol, 31
Brompheniramine Maleate 5 15 15
Busulfan acetone, 45
Butabarbital Sodium 2 7 7000 10,000
Butamben 7000
Butylated Hydroxyanisole 4.0 2.0 1.2
Butylated Hydroxytoluene 4.0 1.1 1.1
Caffeine (hydrous) 50 75 6 600
Calcium Chloride 0.7 0.2 4 boiling alcohol, 2
Calcium Gluconate 30 5
(slowly)
Calcium Hydroxide 630 1300
Calcium Lactate 20
Calcium Pantothenate 3
Calcium Sulfate 375 485
Camphor 800 1 0.5 1
Carbinoxamine Maleate <1 1.5 1.5 8300
Carisoprodol 2083 2.5 2.3 acetone, 2.5
Cephaloridine 5 1000 10,000 10,000
Cetylpyridinium Chloride 4.5 2.5 4.5
Chloral Betaine 1 4 >10,000 >10,000 0.1 N hydrochloric acid, 1; 0.1 N sodium hydroxide, 1
Chloral Hydrate 0.25 1.3 2 1.5
Chlorambucil acetone, 2
Chloramphenicol 400
Chlordiazepoxide >10,000 50 6250 130
Chlorobutanol 125 1 glycerin, 10
Chlorocresol 260 0.4
Chloroprocaine Hydrochloride 20 100
Chlorpheniramine Maleate 4 10 10
Chlorpromazine 3 2 3 benzene, 2
Chlorpromazine Hydrochloride 1 1.5 1.5
Chlortetracycline Hydrochloride 75 560
Cholesterol 100 dehydrated alcohol, 50
(slowly)
Citric Acid 0.5 2 30
Clindamycin Palmitate Hydrochloride 3 ethyl acetate, 9
Clindamycin Phosphate 2.5 >1000 >1000 >1000
Clioquinol >100,000 3500 120 4500
Cocaine 600 7 1 3.5 olive oil, 12; liquid petrolatum, 80–100
Cocaine Hydrochloride 0.5 3.5 15
Codeine 120 2 0.5 50
Codeine Phosphate 2.5 325 boiling alcohol, 125; water at 80, 0.5
Codeine Sulfate 30 1300 water at 80, 6.5
Colchicine 25 220
Cortisone Acetate 350 4 acetone, 75; dioxane, 30
Cupric Sulfate 3 0.5 500 glycerin, 3
Cyanocobalamin 80
Cyclizine Hydrochloride 115 115 75
Cyproheptadine Hydrochloride 275 35 26 methanol, 1.5
Dehydrocholic Acid 100 35 2200 (15) acetic acid at 15, 135; acetone at 15, 130; benzene at 15, 960; ethyl acetate at 15, 135
Demeclocycline 200 methanol, 40
Demeclocycline Hydrochloride 60 methanol, 50
Denatonium Benzoate 20 2.4 2.9 5000
Desipramine Hydrochloride 12 14 3.5 >10,000
Dexamethasone Sodium Phosphate 2
Dexbrompheniramine Maleate 1.2 2.5 2 3000
Dexchlorpheniramine Maleate 1.1 2 1.7 2500
Dextroamphetamine Sulfate 10 800
Dextromethorphan Hydrobromide 65
Dextrose 1 100
Diazepam 333 16 2 39
Dibucaine 4600 0.7 0.5 1.4
Dicyclomine Hydrochloride 13 5 2 770 glacial acetic acid, 2
Diethylpropion Hydrochloride 0.5 3 3
Digitoxin 150 40
Dihydroergotamine Mesylate 125 90 175 2600
Dimercaprol 20
Dimethisterone 3 0.7
Diphenhydramine Hydrochloride 1 2 2 acetone, 50
Disulfiram >5000 30 15
Docusate Calcium 3300 >1 >1 >1
Docusate Sodium 70
(slowly)
Doxapram Hydrochloride 50
Doxylamine Succinate 1 2 2 370
Droperidol 10,000 140 4 500
Dyclonine Hydrochloride 60 24 2.3 >10,000 hexane, >10,000
Dydrogesterone >10,000 40 2 200
Echothiophate Iodide 1 dehydrated alcohol, 25; methanol, 3
Edrophonium Chloride 0.5 5
Enalaprilat 200 >1000 dimethylformamide, 40; methanol, 68
Ephedrine 20 0.2
Ephedrine Hydrochloride 3 14
Ephedrine Sulfate 1.3 90
Epinephrine Bitartrate 3
Ergotamine Tartrate 500 500
Erythromycin 1000
Erythromycin Estolate 20 10 acetone, 15
Estradiol 28 435 150
Estradiol Cypionate >10,000 40 7 2800
Estrone 250 (15) 110 (15) boiling alcohol, 50; boiling chloroform, 80; acetone at 50, 50; boiling acetone, 33; boiling benzene, 145
Estropipate >2000 >2000 >2000 >2000 warm alcohol, 500
Ethacrynic Acid 1.6 6 3.5
Ether1 12
Ethyl Vanillin 100 2
(50)
Ferrous Gluconate 5
Ferrous Sulfate 1.5 0.5
Flumethasone Pivalate >10,000 89 350 2800
Fluocinolone Acetonide >1000 45 25 350
Fluorometholone >10,000 200 2200 >10,000
Fluphenazine Enanthate <1 <1 2
Fluphenazine Hydrochloride 1.4 6.7
Flurandrenolide 72 10 methanol, 25
Flurazepam Hydrochloride 2 4 90 5000 methanol, 3; isopropanol, 69; benzene, 2500; petroleum ether, 5000
Fluroxene 220
Fructose 15 methanol, 14
Gentian Violet 10 glycerin, 15
Glyceryl Monostearate 10.0 100.0 methanol, 100; isopropyl alcohol, 33
Glycine 4 1254 water at 50, 2.6; at 75, 1.9; at 100, 1.5
Glycopyrrolate 4.2 30 260 35,000
Guaifenesin 60–70
Halazone >1000 140 >1000 >2000
Haloperidol >10,000 60 15 200
Heparin Sodium 20
Histamine Phosphate 4
Homatropine Hydrobromide 6 40 420
Hydralazine Hydrochloride 25 500
Hydrocortisone 40 acetone, 80
Hydrocortisone Acetate 230 200
Hydrocortisone Sodium Phosphate 1.5
Hydroflumethiazide >5000 39 >5000 2500
Hydromorphone Hydrochloride 3
Hydroquinone 17 4 51 16.5
Hydroxocobalamin 50 100 10,000 10,000
Hydroxyzine Hydrochloride 1 4.5 13 >1000
Hydroxyzine Pamoate >1000 700 >1000 >1000 dimethylformamide, 10; 10 N sodium hydroxide, 3.5
Hyoscyamine Hydrobromide 2.5 1.7 2300
Hyoscyamine Sulfate 0.5 5
Ichthammol 10
Indigotindisulfonate Sodium 100
Indomethacin 50 30 40
Iodine 3000 13 carbon disulfide, 4; glycerin, 80
Ipodate Sodium <1 2 dimethylacetamide, 2; dimethylformamide, 3.5; dimethylsulfoxide, 3.5
Isoniazid 8 50
Isopropamide Iodide 50 10 5
Isopropyl Alcohol <1 <1 <1 <1
Isoproterenol Hydrochloride 3 50
Isoproterenol Sulfate 4 >2000 >2000 >2000
Isoxsuprine Hydrochloride 500 100 >10,000 >10,000 0.1 N hydrochloric acid, 2500; 0.1 N sodium hydroxide, 100
Ketamine Hydrochloride 4 14 60 >10,000 methanol, 6; absolute alcohol, 60
Lactose 5 2.6
(slowly)
Levorphanol Tartrate 50 120
Levothyroxine Sodium 700 300
Lisinopril 10 >10,000 >10,000 >10,000 methanol, 70
Magnesium Hydroxide >10,000 >10,000 >10,000 >10,000
Magnesium Sulfate 0.8 0.5 glycerin, 1 (slowly)
Mannitol 5.5
Menadione 60 benzene, 10; vegetable oils, 50
Mesoridazine Besylate 1 11 3 6300
Methacholine Chloride 1.2 1.7 2.1
Methacrylic Acid Copolymer water in methanol (3 in 100), 10; water in alcohol (3 in 100), 10; water in isopropyl alcohol (3 in 100), 10; water in acetone (3 in 100), 10
Methacycline Hydrochloride 100 300 >1000 >1000 0.1 N sodium hydroxide, 25
Methdilazine Hydrochloride 2 2 6 >10,000 0.1 N hydrochloric acid, 1; 0.1 N sodium hydroxide, 1
Methenamine 1.5 12.5 10 320
Methenamine Mandelate 10 20 350
Methimazole 5 5 4.5 125
Methocarbamol 40
(20)
Methotrimeprazine 10 10 2 methanol, 10
Methoxyflurane 500 <1 <1 <1
Methsuximide 350 3 <1 2
Methyclothiazide >10,000 92.5 >10,000 2700
Methylbenzethonium Chloride 0.8 0.9 >10,000 0.7
Methylene Blue 25 65
Methylergonovine Maleate 100 175 1900 8400
Methylparaben 400 3 10 water at 80, 50
Methylprednisolone 10,000 100 800 800
Methylprednisolone Acetate 1500 400 250 1500
Methylprednisolone Sodium Succinate 1.5 12 >10,000 >10,000
Methysergide Maleate 200 165 3400 >10,000
Miconazole >100,000 9.5 2 15 isopropyl alcohol, 4; propylene glycol, 9; methanol, 5.3
Miconazole Nitrate 6250 312 525 50,000 isopropyl alcohol, 1408; propylene glycol, 119; methanol, 75
Morphine Sulfate 16 570 alcohol at 60, 240; water at 80, 1
Nalidixic Acid >1000 910 29 >1000
Neomycin Sulfate 1
Niacin 60
Niacinamide 1.5 10 5.5
Nifedipine >10,000 acetone, 10
Nitrofurazone 4200 590 propylene glycol, 350
Nitromersol >2000 >2000 >2000 >2000
Norepinephrine Bitartrate 2.5 300
Norethindrone Acetate >10,000 10 <1 18 dioxane, 2
Nortriptyline Hydrochloride 90 30 20 methanol, 10
Oxandrolone 5200 57 <5 860 acetone, 69
Oxazepam >10,000 220 270 2200
Oxtriphylline 1
Oxymetazoline Hydrochloride 6.7 3.6 862
Oxymetholone >10,000 40 5 82 dioxane, 14
Oxymorphone Hydrochloride 4 100 >1000 >1000 methanol, 25
Oxytetracycline 4150 >10,000 6250 absolute alcohol, 66
Oxytetracycline Calcium >1000 >1000 >1000 >1000 0.1 N sodium hydroxide, 15
Papaverine Hydrochloride 30 120
Paraldehyde1 10 17
Paramethasone Acetate 50 methanol, 40
Paromomycin Sulfate <1 >10,000 >10,000 >10,000
Pectin 20
Penicillin G Benzathine 5000 65
Sterile Penicillin G Procaine 250 30 60
Sterile Penicillin G Sodium 40
Penicillin V Benzathine 3200 330 42 910 acetone, 37
Penicillin V Potassium 150
Pentazocine >1000 11 2 42
Pentazocine Hydrochloride 30 20 4 >10,000
Pentobarbital >2000 4.5 4.0 10
Pentolinium Tartrate 0.5 475 >1000 >2000
Perphenazine 7 acetone, 13
Phenazopyridine Hydrochloride <10 20 59 331 >5000 cold water, 300; glycerin, 100
Phenindamine Tartrate 40 350
Phenmetrazine Hydrochloride 0.4 2 2
Phenobarbital 1000 10
Phenol 15 mineral oil, 70
Phentolamine Mesylate 1 4 700
Phenylethyl Alcohol 60 <1 <1 <1 alcohol solution (1 in 2), 2; diethylphthalate, <1; benzyl benzoate, <1
Phenylmercuric Acetate 180 225 6.8 200
Phenylmercuric Nitrate 600
Phenylpropanolamine Hydrochloride 1.1 7.4 4100
Physostigmine Salicylate 75 16 6 250
Physostigmine Sulfate 4 0.4 1200
Pilocarpine Hydrochloride 0.3 3 360
Pilocarpine Nitrate 4 75
Piminodine Esylate >1000 6 2 >1000
Pimozide >10,000 1000 10 1000 acetone, 100; methanol, 1000; 0.1 N hydrochloride acid, >1000
Polyethylene Glycol 1540 1 3 absolute alcohol, 100
Polyethylene Glycol 4000 4 2.5 2
Potash, Sulfurated 2
Potassium Acetate 0.5 0.2 3
Potassium Alum 7 0.3
Potassium Benzoate 2 75 alcohol solution (9 in 10), 50
Potassium Chloride 2.8 2
Potassium Citrate 1 glycerin, 2.5
Potassium Gluconate 3
Potassium Hydroxide 1 3 glycerin, 2.5
Potassium Iodide 0.7 0.5 22 glycerin, 2
Potassium Permanganate 15 3.5
Potassium Sodium Tartrate 1
Potassium Sorbate 4.5 35 >1000 >1000
Pramoxine Hydrochloride 35
Prednisolone 30 180 acetone, 50
Prednisolone Acetate 120
Prednisolone Hemisuccinate 4170 6.3 1064 248
Prednisolone Sodium Phosphate 4 methanol, 13
Prednisone 150 200
Prilocaine Hydrochloride 3.5 4.2 175
Primaquine Phosphate 15
Primidone 2000 200
Procaine Hydrochloride 1 15
Prochlorperazine Edisylate 2 1500
Prochlorperazine Maleate 1200
Procyclidine Hydrochloride 35 9 6 11,000
Promazine Hydrochloride 3
Propoxycaine Hydrochloride 2 10 >10,000 80
Propoxyphene Napsylate 10,000 15 10
Propylhexedrine >500 0.4 0.2 0.1
Propylparaben 2500 400 1.5 3
Protriptyline Hydrochloride 2 3.5 2.5 >10,000
Pseudoephedrine Hydrochloride 0.5 3.6 91 7000
Pyrazinamide 67 135 1000 absolute alcohol, 175; methanol, 72
Pyridoxine Hydrochloride 5 115
Pyrilamine Maleate 0.5 3 2 absolute alcohol, 15
Pyrimethamine 200 125
Pyrrocaine Hydrochloride 1.5 12 8
Quinidine Sulfate 100 10 15
Quinine Sulfate 500 120
Reserpine 1800 6
Resorcinol 1 1
Rotoxamine Tartrate 10 100 >10,000 >10,000
Saccharin 290 25 31
Saccharin Calcium 2.6 4.7
Saccharin Sodium 1.5 50
Salicylic Acid 460 15 3 45 3 benzene, 135
Scopolamine Hydrobromide 1.5 20
Secobarbital 0.5 N sodium hydroxide, 8.5
Selenium Sulfide 161 1667
Sennosides 35 2100 3700 6100
Silver Nitrate 0.4 0.1 30 boiling alcohol, 6.5
Simethicone2 >10,000 102 102 benzene, 102; absolute alcohol, >10,000
Sodium Acetate 0.8 0.6 19
Sodium Ascorbate 1.3
Sodium Benzoate 2 75 90 percent alcohol, 50
Sodium Bicarbonate 12
Sodium Bisulfite 4
Sodium Borate 16 1 glycerin, 1
Sodium Carbonate 3 1.8
Sodium Chloride 2.8 2.7 glycerin, 10
Sodium Citrate (hydrous) 1.5 0.6
Sodium Fluoride 25
Sodium Formaldehyde Sulfoxylate 3.4 510 175 180
Sodium Hydroxide 1
Sodium Iodide 0.6 2 glycerin, 1
Sodium Lauryl Sulfate 10
Sodium Nitrite 1.5
Sodium Phosphate, Dried 8
Sodium Propionate 1 0.65 24 >10,000 >10,000
Sodium Thiosulfate 0.5
Sorbic Acid 1000 10 15 30 absolute alcohol, 8; methanol, 8; propylene glycol, 19
Sorbitol 0.45
Stanozolol >1000 41 74 370
Stearic Acid 20 2 3
Stibophen 1 >10,000 >10,000 10,000
Succinylcholine Chloride 1 350
Sucrose 0.5 0.2 170
Sucrose Octaacetate 1100 11 acetone, 0.3; benzene, 0.6; toluene, 0.5
Sulconazole Nitrate 3333 100 333 pyridine, 10; methanol, 71; acetone, 130; methylene chloride, 286; toluene, 2000; dioxane, 2000
Sulfacetamide Sodium 2.5
Sulfadiazine 13,000 human serum at 37, 620
Sulfadiazine Sodium 2
Sulfadimethoxine 200 2 N hydrochloric acid, 50
Sulfaethidole >3000 75 1300 1700 methanol, 51; acetone, 13; benzene, 2277
Sulfamethizole 2000 38 1900 1900 acetone, 13
Sulfamethoxazole 3400 50 1000 1000 carbon disulfide, 2 (slowly and usually incompletely)
Sulfapyridine 3500 440 acetone, 65
Sulfasalazine >10,000 2900 >10,000 >10,000 methanol, 1500
Sulfisoxazole 7700 boiling alcohol, 10
Sulfisoxazole Acetyl 176 35 1064 methanol, 203
Precipitated Sulfur carbon disulfide, 2 (slowly and usually incompletely) olive oil, 100
Tartaric Acid 0.8 0.5 3 250 methanol, 1.7
Terpin Hydrate 200 35 13 140 140 boiling alcohol, 3
Testolactone 4050
Testosterone 2 100 absolute alcohol, 6
Tetracaine >1000 5 2 2
Tetracycline 2500 50
Tetracycline Hydrochloride 10 100
Tetrahydrozoline Hydrochloride 3.5 7.5 >1000 >1000
Theophylline Sodium Glycinate 6
Thiamine Hydrochloride 1 170
Thiamine Mononitrate 44
Thiethylperazine Maleate 1700 530 >10,000 >10,000
Thimerosal 1 12
Thioguanine 7700
Thiotepa 13 8.3 1.9 4.1
Thiothixene >10,000 2 120 absolute alcohol, 110
Thiothixene Hydrochloride 8 280 >10,000 absolute alcohol, 270
Thymol 1000 1 1 1.5 olive oil, 2
Tolazoline Hydrochloride <1 2 3 >10,000
Triamcinolone Diacetate 13 80 methanol, 40
Triamterene formic acid, 30; 2-methoxyethanol, 85
Triazolam >10,000 1000 25 >10,000 0.1 N hydrochloric acid, 600
Trichlormethiazide 1100 48 5000 1400 dioxane, 9.1; dimethylformamide, 4.35
Trichloroethylene >10,000
Triethylenemelamine 2.5 13 3.6 methanol, 8; acetone, 9.5; benzene, 18
Trifluoperazine Hydrochloride 3.5 11 100
Triflupromazine Hydrochloride <1 <1 1.7
Trimeprazine Tartrate 2 20 5 1800
Trimethobenzamide Hydrochloride 2 59 67 720
Trioxsalen 1150 84 methylenedichloride, 43; 4-methyl-2-pentanone, 100
Tripelennamine Hydrochloride 1 6 6 acetone, 350
Triprolidine Hydrochloride 2.1 1.8 1 2000
Tromethamine 1.8 45.5 >10,000
Tubocurarine Chloride 20 45
Urea 1.5 10 boiling alcohol, 1
Vanillin 100 glycerin, 20; water at 80, 20
Xylometazoline Hydrochloride 35
Zinc Acetate 2.5 30
Zinc Chloride 0.5 1.5 glycerin, 2
Zinc Sulfate 0.6 glycerin, 2.5
1  Solubility data for compounds that ordinarily are liquids at 25 are expressed in terms of the ratio of the volume of solute to the volume of solvent; i.e., 1 mL dissolved in mL of solvent.
2  Liquid phase only; silicon dioxide remains as a residue in these solvents.