Medium: water containing 5.4 mg of sodium lauryl sulfate per mL; 1000 mL.

Apparatus 2: 75 rpm.

Time: 45 minutes.

Procedure— Determine the amount of C17H17ClO6 dissolved from UV absorbances at the wavelength of maximum absorbance at about 291 nm of filtered portions of the solution under test, suitably diluted with a solution of methanol and water (4:1), if necessary, in comparison with a Standard solution having a known concentration of USP Griseofulvin RS in the same medium.

Tolerances— Not less than 80% (Q) of the labeled amount of C17H17ClO6 is dissolved in 45 minutes.

Procedure for content uniformity— Proceed as directed for Procedure for content uniformity in the test for Uniformity of dosage units under Griseofulvin Tablets.

Mobile phase, Standard preparation, and Chromatographic system— Proceed as directed in the Assay under Griseofulvin.

Assay preparation— Weigh and finely powder not less than 20 Tablets and proceed as directed for Assay preparation in the Assay under Griseofulvin Capsules, beginning with “transfer an accurately weighed portion.”

Procedure— Proceed as directed for Procedure in the Assay under Griseofulvin. Calculate the quantity, in mg, of griseofulvin (C17H17ClO6) in the portion of Tablets taken by the formula: in which C is the concentration, in mg per mL, of USP Griseofulvin RS in the Standard preparation, and the other terms are as defined therein.