美国FDA药品溶出方法数据库

药品通用名称	剂型	USP溶出装置	速度	溶出介质	介质体积	建议取样时间（分钟）	更新日期
Molindone HCl	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Momelotinib	Tablet	II (Paddle)	75	22 mM Sodium Acetate Buffer, pH 4.5 w/1.3% SDS	900	10, 15, 20, 30 and 45	2025/02/24
Monomethyl Fumarate	Capsule (Delayed Release)	II (Paddle) Stationary Basket over the Paddle	100	Acid Stage: 0.1 N HCl; Buffer Stage: Phosphate buffer, pH 6.8		Acid Stage: 120; Buffer Stage: 15, 30, 45, 60, 90, 120 and 150	2020/08/27
Montelukast	Granule			Develop a dissolution method			2023/09/15
Montelukast Sodium	Tablet (Chewable)			Develop a dissolution method			2023/09/15
Montelukast Sodium	Tablet			Develop a dissolution method			2023/09/15
Morphine Sulfate	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Morphine Sulfate	Tablet (Extended Release)	I (Basket)	100	Simulated Gastric Fluid [SGF] without enzyme	900	0.25, 0.5, 1, 1.5, 2, 4, 6 and 8 hours	2016/10/20
Morphine Sulfate	Capsule (Extended Release)			Refer to USP			2008/08/11
Morphine Sulfate/Naltrexone HCl	Capsule (Extended Release)	II (Paddle)	50	Acid stage: 0.1 N HCl; Buffer stage: 0.05 Phosphate Buffer, pH 7.5	Acid stage: 500; Buffer stage: 500	Morphine Sulfate: Acid stage: 1 hour; Buffer stage: 1, 3, 5, 8 and 10 hours. Naltrexone HCl: Acid stage: 1 hour; Buffer stage: 1, 12, 24, 48, 73 and 96 hours.	2012/01/26
Moxifloxacin	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Mycophenolate Mofetil	Suspension	II (Paddle)	40	0.1 N HCl	900	5, 10, 20 and 30	2004/02/10
Mycophenolate Mofetil	Capsule	II (Paddle)	40	0.1 N HCl	900	5, 10, 20 and 30	2004/02/10
Mycophenolate Mofetil	Tablet	II (Paddle)	50	0.1 N HCl	900	5, 10, 15 and 30	2004/02/10
Mycophenolic acid	Tablet (Delayed Release)	II (Paddle)	50	Acid Stage: 0.1 N HCl; Buffer Stage: Buffer Solution, pH 6.8 (After initial 120 mins., 250 mL of 0.2 M sodium phosphate solution is added to acid stage medium. The pH of the mixture is adjusted to 6.8 using 0.2 M sodium phosphate, 2 N sodium hydroxide, or concentrated HCl acid solution if necessary.)	750 (Acid), 1000 (Buffer)	120 (Acid), 10, 20, 30, 45 and 60 (Buffer)	2008/12/19
Nabilone	Capsule	II (Paddle)	50	0.1% Tween 80 solution	1000	15, 30, 45 and 60	2008/07/14
Nabumetone	Tablet			Develop a dissolution method			2024/01/03
Nadolol	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Naldemedine	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Naloxegol Oxalate	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02