美国FDA药品溶出方法数据库

药品通用名称	剂型	USP溶出装置	速度	溶出介质	介质体积	建议取样时间（分钟）	更新日期
Methocarbamol	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Methotrexate Sodium	Tablet			Develop a dissolution method			2024/01/03
Methoxsalen	Capsule			Develop a dissolution method			2024/01/03
Methscopolamine Bromide	Tablet			Refer to USP			2018/02/15
Methyldopa	Tablet	II (Paddle)	50	0.1 N HCl	900	10, 15, 30 and 45	2025/01/17
Methylergonovine Maleate	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Methylnaltrexone Bromide	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Methylphenidate	Tablet (Extended Release, Orally Disintegrating )	II (Paddle)	75	Acid Stage: 0.1 N HCl; Buffer Stage: Phosphate Buffer, pH 6.8	Acid Stage: 900 mL; Buffer Stage: 1000 mL	Acid Stage: 15, 30, 60, 120 minutes; Buffer Stage: 1, 2, 3, 4, 6 and 8 hours	2017/11/16
Methylphenidate	Capsule (Extended Release)			Develop a dissolution method			2023/09/15
Methylphenidate	Transdermal Patch	VI (Cylinder)	50	0.01 N HCl at 32ºC	900	0.5, 1.5, 3, 4 hours and until at least 80% released	2008/04/15
Methylphenidate	Tablet (Extended Release)			Develop a dissolution method			2024/01/03
Methylphenidate (BX)	Capsule (Extended Release)	I (Basket)	75	0-2 hrs:0.01 N HCl. 2-10 hrs: Phosphate Buffer, pH 6.8.	0-2 hrs: 500. 2-10 hrs:500	0.5, 1, 3, 6, 8 and 10 hours	2007/07/25
Methylphenidate HCl	Powder for Suspension (Extended Release)	II (Paddle)	75	0.4 M Phosphate Buffer, pH 4.5	900	0.25, 0.5, 1, 2, 3, 4, 6 and 8 hours	2016/06/02
Methylphenidate HCl	Tablet (Extended Release, Chewable)	II (Paddle)	75	0.4M KH2PO4 solution (degas)	900	0.25, 0.5, 1, 2, 3, 4, 6, 8 hours	2016/03/17
Methylphenidate HCl	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Methylphenidate HCl	Capsule (Extended Release)	I (Basket)	100	Acid Stage:(First 2 hours) 0.01 N HCl; Buffer Stage (2-10 hours): Phosphate Buffer, pH 6.0	Acid: 500 mL; Buffer: 500 mL	0.5, 1, 2, 4, 6, and 10 hours	2016/10/20
Methylphenidate HCl	Tablet (Chewable)			Develop a dissolution method			2023/09/15
Methylphenidate HCl (25 mg, 35 mg, 45 mg, 55 mg, 70 mg and 85 mg)	Capsule (Extended Release)	II (Paddle) with sinker	75	Acid Stage:(0-6 hours) Simulated Gastric Fluid [SGF, pH 1.2] without enzyme; Buffer Stage (after six hours in acid stage): Phosphate Buffer, pH 7.4		Acid Stage: 0.5, 1, 2, 4, 6 hours; Buffer Stage: 1, 2, 4, 6, 8 and 10 hours	2020/04/02
Methylprednisolone	Tablet			Develop a dissolution method			2024/01/03
Methylprednisolone Acetate	Injectable Suspension	IV (Flow-Through Cell-Open system)		0.55 % SDS		15, 30, 45, 60, 90 and 120	2009/10/08