美国FDA药品溶出方法数据库

药品通用名称	剂型	USP溶出装置	速度	溶出介质	介质体积	建议取样时间（分钟）	更新日期
Mesalamine (1.2 gram)	Tablet (Delayed Release)	II (Paddle)	100	Acid stage (A): 100 mM HCl Buffer stage (B): Phosphate Buffer, pH 6.4 Buffer stage (C): Phosphate Buffer, pH 7.2	Acid stage (A): 750 mL; Buffer stage (B): 950 mL; Buffer stage (C): 960 mL	Acid stage (A): 2 hours; Buffer stage (B): 1 hour; Buffer stage (C): 1, 2, 4, 6 and 8 hours	2009/06/10
Mesalamine (250 mg and 500 mg)	Capsule (Extended Release)			Refer to USP			2009/06/10
Mesalamine (375 mg)	Capsule (Extended Release)	I (Basket)	100	Acid Stage: 0.1N HCl Buffer stage: Phosphate Buffer, pH 6.8	Acid stage: 750 mL; Buffer stage: 1000 mL	Acid stage: 2 hours; Buffer stage: 0.5, 1, 2, 4, 7 and 9 hours	2009/06/10
Mesalamine (400 mg and 800 mg)	Tablet (Delayed Release)			Refer to USP			2010/11/05
Mesalamine Enema	Rectal Enema	II (Paddle)	50	Phosphate Buffer, pH 7.2	900	5, 10, 15, and 30	2007/06/18
Mesna	Tablet	II (Paddle)	50	0.06 N HCl	500	5, 10, 15, 20 and 30	2004/02/09
Mestranol/Norethindrone	Tablet			Refer to USP			2010/03/25
Metaxalone	Tablet			Develop a dissolution method			2024/01/03
Metformin HCl	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Metformin HCl	For Suspension (Extended Release)	II (Paddle)	100	Phosphate Buffer, pH 6.8	1000	0.5, 1, 2, 3, 4, 6, 8, 10 and 12 hours	2020/01/30
Metformin HCl	Tablet (Extended Release)			Refer to USP			2008/12/12
Metformin HCl (MET); Sitagliptin (SIT)	Tablet (Extended Release)	II (Paddle) with sinker	75	Phosphate buffer, pH 6.8	900	MET: 1, 2, 3, 4, 6, 8, 10, and 12 hours; SIT: 10, 20, 30, 45 and 60	2023/07/07
Metformin HCl/Pioglitazone HCl	Tablet	II (Paddle)	50	pH 2.5 McIlvaine buffer (0.1 M Citric acid adjusted to pH 2.5 with 0.2 M Na2HPO4)	900	10, 20, 30 and 45	2007/01/03
Metformin HCl/Saxagliptin	Tablet (Extended Release)	I (Basket)	100	Phosphate Buffer, pH 6.8	1000	Metformin: 1, 2, 3, 4, 6, 8, 10 and 12 hours. Saxagliptin: 5, 10, 15, 20 and 30 minutes	2012/01/26
Metformin HCl/Sitagliptin Phosphate	Tablet	II (Paddle)	75	0.025 M NaCl	900	10, 15, 20 and 30	2008/10/06
Metformin/Repaglinide	Tablet	II (Paddle)	50	Citric acid/phosphate buffer, pH 5.0	900	5, 10, 15, 20 and 30	2009/10/30
Methadone HCl	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Methazolamide	Tablet	II (Paddle)	100	pH 4.5 Acetate Buffer	900	10, 15, 20, 30 and 45	2015/05/28
Methenamine Hippurate	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Methimazole	Tablet			Refer to USP			2008/01/14