美国FDA药品溶出方法数据库

药品通用名称	剂型	USP溶出装置	速度	溶出介质	介质体积	建议取样时间（分钟）	更新日期
Lamivudine/Zidovudine	Tablet			Refer to USP			2017/11/02
Lamivudine/Zidovudine + Efavirenz	Tablet (Copackage)	II (Paddle)	Lamivudine and Zidovudine: 75	Lamivudine and Zidovudine: 0.1 N HCl Efavirenz: Develop a dissolution method	Lamivudine and Zidovudine: 1000	10, 20, 30, and 45	2023/09/15
Lamivudine/Zidovudine + Nevirapine	Tablet (Copackage)	II (Paddle)	50	Lamivudine and Zidovudine: Develop a dissolution method Nevirapine: 0.06 M HCl (pH 1.2)	900	10, 15, 30, 45 and 60	2023/09/15
Lamivudine/Zidovudine/ Nevirapine	Tablet	II (Paddle)	50	0.01 N HCl	900	10, 15, 30, 45 and 60	2007/01/03
Lamotrigine	Tablet (Chewable dispersible)	II (Paddle)	50	0.1 N HCl	900	5, 10, 15, 20 and 30	2008/01/14
Lamotrigine	Tablet, For Suspension			Refer to USP			2023/02/09
Lamotrigine	Tablet (Regular)	II (Paddle)	50	0.1 N HCl	900	5, 10, 15, 20 and 30	2006/03/04
Lamotrigine	Tablet (Extended Release)			Refer to USP			2016/02/18
Lansoprazole	Capsule (Delayed Release)			Refer to USP			2008/11/04
Lansoprazole	Tablet (Delayed Release, Orally Disintegrating)	II (Paddle)	75	Acid Stage: 0.1 N HCl; Buffer Stage: Phosphate Buffer, pH 6.8 with 5 mM Sodium Dodecyl Sulfate	500 (Acid), 900 (Buffer)	60 (Acid), 10, 20, 30 and 45 (Buffer)	2008/11/04
Lanthanum Carbonate	Chewable Tablet	Reciprocating Cylinder (Apparatus 3 modified)	10 dpm (dip rate per minute)	0.25 N HCl	900 (modified from the standard apparatus 3 vessel to achieve sink condition)	10, 20, 30 and 45	2007/01/03
Lapatinib Ditosylate	Tablet	II (Paddle)	55	2% Polysorbate 80 in 0.1 N HCl	900	10, 15, 30 and 45	2009/10/30
Lasmiditan Succinate	Tablet			Refer to FDA's Dissolution Guidance, 2018			2022/05/12
Ledipasvir/Sofosbuvir	Tablet	II (Paddle)	75	1.5% Polysorbate 80 in 10 mM Potassium Phosphate Buffer with 0.0075 mg/mL Butylated Hydroxytoluene (BHT), pH 6.0	900	5, 10, 15, 20, 30, 45 and 60	2015/08/27
Ledipasvir/Sofosbuvir	Pellets	II (Paddle)	75	1.0% polysorbate 80 in 25 mM Potassium Phosphate Buffer, with 0.005 mg/mL Butylated Hydroxytoluene (BHT), pH 5.5	900	5, 10, 15, 20, 30, 45 and 60	2021/08/19
Lefamulin Acetate	Tablet	II (Paddle)	50	0.1 N HCl	1000	10, 20, 30, 45, 60, 75, and 90	2021/04/22
Leflunomide	Tablet			Develop a dissolution method			2023/09/15
Leflunomide (100 mg)	Tablet			Develop a dissolution method			2023/09/15
Lemborexant	Tablet	II (Paddle)	50	0.1 N HCl	900	5, 10, 15, 20 and 30	2022/05/12
Lenacapavir Sodium	Tablet	II (Paddle) with sinkers	75	30 mM potassium phosphate, pH 6.0 with 2.0% Cremophor EL	900	10, 15, 20, 25, 30, 45 and 60	2024/02/05