美国FDA药品溶出方法数据库

药品通用名称	剂型	USP溶出装置	速度	溶出介质	介质体积	建议取样时间（分钟）	更新日期
Itraconazole	Capsule	II (Paddle)	100	SGF without Enzyme	900	10, 20, 30, 45, 60 and 90	2004/02/04
Itraconazole	Tablet	II (Paddle)	75	0.1 N HCl	900	5, 15, 30, 45, 60, 75 and 90	2013/08/15
Ivabradine HCl	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Ivacaftor	Tablet	II (Paddle) with sinker	65	50 mM Sodium Phosphate Buffer with 0.7% Sodium Dodecyl Sulfate (SDS), pH 6.8	900	5, 10, 15, 20 and 30	2015/06/25
Ivacaftor/lumacaftor	Tablet	Lumacaftor: II (Paddle); Ivacaftor: II (Paddle)	Lumacaftor:65; Ivacaftor: 65	Lumacaftor: 0.5% (w/v) CTAB in 50 mM Sodium Acetate Trihydrate buffer (pH 4.5); Ivacaftor: 0.4% (w/v) SLS in 50 mM Sodium Phosphate buffer (pH 6.8)	Lumacaftor: 900; Ivacaftor: 900	5, 10, 15, 20 and 30	2016/03/17
Ivacaftor/Tezacaftor [FDC: IVA+ TEZ]; Ivacaftor [IVA]	Tablet/Tablet (Copackage)	II (Paddle) with option to use a sinker	FDC: IVA: 65/TEZ:75; IVA: 65	FDC: IVA: 50 mM Sodium Phosphate Buffer with 0.4% Sodium Dodecyl Sulfate (SDS), pH 6.8/TEZ: 0.2 SDS% in 0.1 N HCl; IVA: 50 mM Sodium Phosphate Buffer with 0.7% SDS, pH 6.8;	FDC: IVA: 900/ TEZ: 900; IVA: 900	5, 10, 15, 20, 30 and 45	2019/03/07
Ivermectin	Tablet	II (Paddle)	50	0.5% SDS in 0.01 M Monobasic Sodium Phosphate, pH 7.0	900	10, 20, 30, 45 and 60	2004/02/04
Ivosidenib	Tablet	II (Paddle)	50	50 mM Phosphate Buffer pH, 6.8 with 0.6% sodium dodecyl sulfate (SDS),	900	10, 15, 20, 30 and 45	2020/08/27
Ixazomib Citrate	Capsule	I (Basket)	100	0.1 N HCl	500	5, 10, 15, 20 and 30	2016/10/20
Ketoconazole	Tablet	I (Basket)	100	Simulated gastric fluid w/o pepsin	800	15, 30, 45, 60 and 90	2007/01/03
Ketoprofen	Capsule	II (Paddle with sinker)	50	0.05M Potassium Phosphate Buffer, pH 7.4	1000	10, 20, and 30	2023/02/09
Ketoprofen	Tablet	II (Paddle)	50	SIF Buffer without enzyme, pH 7.4	900	10, 20, 30, 45 and 60	2004/02/05
Ketorolac Tromethamine	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Labetalol HCl	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Lacosamide	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Lacosamide	Capsule (Extended Release)	I (Basket)	100	Phosphate Buffer, pH 6.8	900	0.5, 1, 2, 3, 4, 5, 6, 8, 10 and 12 hours	2024/05/31
Lamivudine	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Lamivudine 150 mg/Zidovudine 300mg Tablets and Abacavir Sulfate 300 mg Tablets-co-packaged	Tablet	II (Paddle)	75	0.1 N HCl	900	5, 10, 15, 20, 30 and 40	2007/01/03
Lamivudine/Raltegravir Ka	Tablet			Develop a dissolution method			2023/09/15
Lamivudine/Stavudine/Nevirapine	Tablet	II (Paddle)	75	0.1 N HCl	900	10, 20, 30, 45 and 60	2007/01/03