美国FDA药品溶出方法数据库

药品通用名称	剂型	USP溶出装置	速度	溶出介质	介质体积	建议取样时间（分钟）	更新日期
Esomeprazole Magnesium	Tablet (Delayed Release)	II (Paddle)	100	Acid stage: 0.1 N HCl; Buffer stage: Phosphate Buffer, pH 6.8	Acid stage: 300; Buffer stage: 1000	Acid stage: 120; Buffer stage: 10, 20, 30, 45 and 60	2016/10/20
Estazolam	Tablet			Develop a dissolution method			2023/09/15
Esterified Estrogens	Tablet			Develop a dissolution method			2023/09/15
Estradiol	Vaginal Insert	III (Reciprocating Cylinder)	30 dips/min	0.1 N HCl with 0.5% SLS	250	30, 60, 90 and 120	2024/11/01
Estradiol	Vaginal Tablet	I (Basket)	40	Phosphate Buffer, pH 4.75 ± 0.05	500	1, 2, 3, 5, 8, 10 and 12 hours	2009/07/21
Estradiol	Vaginal Ring	Incubator shaker	130	0.9% Saline	250	1, 9, 16, 17, 18, 19, 45 days	2007/01/03
Estradiol (0.014 mg/24 hr)	Film, Transdermal (Extended Release)			Develop a method to characterize in vitro release			2010/10/28
Estradiol (0.025 mg/24 hr, 0.0375 mg/24 hr, 0.05 mg/24 hr, 0.06 mg/24 hr, 0.075 mg/24 hr and 0.1 mg/24 hr)	Film, Transdermal (Extended Release)			Develop a method to characterize in vitro release			2010/10/28
Estradiol (Test 1) (0.025 mg/24 hr, 0.0375 mg/24 hr, 0.05 mg/24 hr, 0.075 mg/24 hr and 0.1 mg/24 hr)	Film, Transdermal (Extended Release)	VI (Cylinder) attach the patch to a disk at the bottom of the cylinder	50	Water at 32 ± 0.5°C	0.025 mg/24 hr and 0.0375 mg/24 hr: 500 mL; 0.05 mg/24 hr, 0.075 mg/24 hr and 0.1 mg/24 hr: 900 mL	1, 2, 4, 6, 8, 10 and 12 hours	2010/10/28
Estradiol (Test 2) (0.05 mg/24 hr and 0.1 mg/24 hr)	Film, Transdermal (Extended Release)	V (Paddle over Disk) with a stainless steel disk	50	Water at 32 ± 0.5°C	900	6, 12, 18, 24, 36, 48, 60, 72 and 96 hours	2010/10/28
Estradiol (Test 3) 0.0375 mg/24 hr, 0.05 mg/24 hr, 0.075 mg/24 hr and 0.1 mg/24 hr)	Film, Transdermal (Extended Release)	VI (Cylinder) attach the patch to the cylinder with double-sided tape	50	Water at 32 ± 0.5°C	0.0375 mg/24 hr: 500 mL; 0.05 mg/24 hr, 0.075 mg/24 hr and 0.1 mg/24 hr: 900 mL	1, 2, 4, 6, 10, 12, 18, 24 and 36 hours	2013/10/31
Estradiol/Levonorgestrel	Film, Transdermal (Extended Release)	V (Paddle over Disk) attach the patch to the stainless steel plate with double-sided tape	50	30% Ethanol in water at 32±0.5°C	660	30, 60, 120, 180, 240 and 300	2023/03/30
Estradiol/Norethindrone Acetate	Film, Transdermal (Extended Release)	V (Paddle over Disk)	50	0.24% SDS in water at 32±0.5°C	0.05 mg/0.14 mg/24 hr: 500; 0.05mg/0.25 mg/24 hr: 900	1, 2, 4, 8, 12 and 14 hours	2023/03/30
Estradiol/Norethindrone Acetate	Tablet			Develop a dissolution method			2024/01/03
Estradiol/Norgestimate (1mg/0.09mg)	Tablet			Develop a dissolution method			2023/09/15
Estradiol/Progesterone	Capsule	III (Reciprocating Cylinder) [40 mesh for bottom and top of the inner tube]		3% sodium lauryl sulfate (SLS) in 0.1N HCl	250	10, 20, 30, 45 and 60	2020/01/30
Estramustine Phosphate Sodium	Capsule			Develop a dissolution method			2023/09/15
Estrogens Conjugated Synthetic A	Tablet			Develop a dissolution method			2023/09/15
Estrogens, Conjugated (EC)/Medroxyprogesterone Acetate (MPA)	Tablet	II (Paddle) with sinker	50	EC: 0.02 M Na Acetate Buffer (pH 4.5); MPA: Develop a dissolution method	900		2023/09/15
Estrogens, Conjugated Synthetic B	Tablet			Develop a dissolution method			2023/09/15