美国FDA药品溶出方法数据库

药品通用名称	剂型	USP溶出装置	速度	溶出介质	介质体积	建议取样时间（分钟）	更新日期
Eltrombopag Olamine	Tablet	II (Paddle)	50	0.5% Polysorbate 80 in Phosphate Buffer, pH 6.8	900	10, 15, 20, 30, 45, and 60	2012/06/07
Eltrombopag Olamine	Suspension	II (Paddle)	50	50 mM potassium phosphate in water, pH 6.8 with 0.2% polysorbate 80	750	4, 8, 12, 15 and 20	2016/10/20
Eluxadoline	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Elvitegravir	Tablet	II (Paddle) with sinker	75	2.0% w/v Polysorbate 80 in 0.01 N HCl (pH 2.0) at 37 ºC	700 mL for 85 mg tablets; 1000 mL for 150 mg tablets 1000 mL for 150 mg tablets	10, 20, 30, 45 and 60	2015/12/24
Empagliflozin	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Empagliflozin/ Metformin HCl	Tablet (Extended Release)	I (Basket)	100	Phosphate Buffer, pH 6.8	900	Metformin: 1, 2, 4, 6, 8, 10 and 12 hours: Empagliflozin: 10, 15, 20, 30, 45 and 60 minutes;	2017/01/19
Empagliflozin/Linagliptin	Tablet	II (Paddle)	50	pH 6.8 Phosphate Buffer	900	10, 15, 20, 30 and 45	2015/12/24
Empagliflozin/Linagliptin/Metformin HCl	Tablet (Extended Release)	I (Basket)	100	Phosphate Buffer, pH 6.8	900	Metformin: 1, 2, 4, 6, 8, 10 and 12 hours: Empagliflozin and Linagliptin: 10, 15, 20, 30, 45 and 60 minutes	2020/04/02
Empagliflozin/Metformin HCl	Tablet	II (Paddle)	50	Phosphate Buffer, pH 6.8 (degas)	900	5, 10, 15, 20 and 30	2016/06/30
Emtricitabine	Capsule			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Emtricitabine/Rilpivirine HCl/Tenofovir Alafenamide Fumarate	Tablet	II (Paddle	75	Rilpivirine (RPV): 0.5% Polysorbate 20 in 0.01 N HCl; Emtricitabine (ETC) and Tenofovir alafenamide (TAF): 50 mM Sodium Citrate, pH 5.5,	RPV: 1000 mL; ETC and TAF: 500 mL	5, 10, 15, 20, 30 and 45	2016/07/28
Emtricitabine/Rilpivirine HCl/Tenofovir Disoproxil Fumarate	Tablet	II (Paddle) with sinker	75	0.5%(w/w) polysorbate 20 in 0.01N HCl (pH 2.0)	1000	Emtricitabine and Tenofovir: 5, 10, 15, 20 and 30; Rilpivirine: 10, 20, 30, 45, 60, 75, 90 and 120	2015/01/15
Emtricitabine/Tenofovir Alafenamide Fumarate	Tablet	II (Paddle	75	50 mM Sodium Citrate buffer, pH 5.5	500	5, 10, 15, 20, 30 and 45	2016/07/28
Emtricitabine/Tenofovir Disoproxil Fumarate	Tablet	II (Paddle)	50	0.01 N HCl	900	5, 10, 15, 30 and 45	2007/01/03
Enalapril Maleate	Tablet			Refer to USP			2008/09/03
Encorafenib	Capsule	II (Paddle) with sinker	100	Ammonium acetate buffer, pH 4.5	900	15, 30, 45 and 60	2025/03/17
Entacapone	Tablet	II (Paddle)	50	Phosphate Buffer, pH 5.5	900	10, 20, 30 and 45	2004/01/29
Entecavir	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Entrectinib	Capsule	II (Paddle) with Sinker	75	50 mM Potassium Phosphate, pH 6.0 with 0.374% w/v polysorbate 80	1000	15, 20, 30, 45, 60 and 75	2021/08/19
Enzalutamide	Tablet	II (Paddle)	50	Phosphate Buffer, pH 7.5	900	5, 10, 15, 20, 30 and 45	2022/05/12