Perifosine
Structural Formula Vector Image
Title: Perifosine
CAS Registry Number: 157716-52-4
CAS Name: 4-[[Hydroxy(octadecyloxy)phosphinyl]oxy]-1,1-dimethylpiperidinium inner salt
Additional Names: octadecyl-(1,1-dimethylpiperidinio-4-yl)phosphate
Manufacturers' Codes: D-21266; KRX-0401; NSC-639966
Molecular Formula: C25H52NO4P
Molecular Weight: 461.66
Percent Composition: C 65.04%, H 11.35%, N 3.03%, O 13.86%, P 6.71%
Literature References: Synthetic alkylphosphocholine anticancer agent. Inhibits the phosphatidylinositol 3-kinase regulated Akt/PKB survival pathway and induces apoptosis. Prepn: G. Nössner et al., DE 4222910; eidem, US 6172050 (1994, 2001 both to Asta Medica). Mechanism of action study: G. A. Ruiter et al., Anti-Cancer Drugs 14, 167 (2003). LC-ESI-MS determn in plasma: E. W. Woo et al., J. Chromatogr. B 759, 247 (2001). Biodistribution and tumor uptake: S. R. Vink et al., Invest. New Drugs 23, 279 (2005). Clinical pharmacokinetics: M. Crul et al., Eur. J. Cancer 38, 1615 (2002); evalution in advanced cancer: L. Van Ummersen et al., Clin. Cancer Res. 10, 7450 (2004).
Properties: Crystals from methyl ethyl ketone, mp 271-272° (dec).
Melting point: mp 271-272° (dec)
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic.

Other Monographs:
OxychloroseneFluroxeneSepiaCadexomer Iodine
p-Bromophenyl IsocyanateDiphenolic AcidMichler's KetoneDichlorvos
Butyl Carbitol®MetyrosineCalcium Polycarbophil2,4'-Biphenyldiamine
UreaMagnesium BenzoateDiborane(6)Chromous Bromide
©2006-2023 DrugFuture->Chemical Index Database