Pancuronium Bromide
Structural Formula Vector Image
Title: Pancuronium Bromide
CAS Registry Number: 15500-66-0
CAS Name: 1,1¢-[(2b,3a,5a,16b,17b)-3,17-Bis(acetyloxy)androstane-2,16-diyl]bis[1-methylpiperidinium] dibromide
Additional Names: 1,1¢-(3a,17b-dihydroxy-5a-androstan-2b,16b-ylene)bis[1-methylpiperidinium] dibromide diacetate; 3a,17b-diacetoxy-2b,16b-dipiperidino-5a-androstane dimethobromide; 2b,16b-dipiperidino-5a-androstane-3a,17b-diol diacetate dimethobromide; poncuronium bromide (rescinded USAN)
Manufacturers' Codes: NA-97; Org-NA-97
Trademarks: Mioblock (Sankyo); Pavulon (Organon)
Molecular Formula: C35H60Br2N2O4
Molecular Weight: 732.67
Percent Composition: C 57.38%, H 8.25%, Br 21.81%, N 3.82%, O 8.73%
Literature References: Aminosteroid, competitive neuromuscular blocker. Prepn: W. R. Buckett et al., Chim. Ther. 2, 186 (1967); eidem, J. Med. Chem. 16, 1116 (1973). Structural studies: Savage et al., J. Chem. Soc. B 1971, 410. Structure-activity correlation: Waser, Anaesthesist 20, 23 (1971). Pharmacology: W. R. Buckett, I. L. Bonta, Fed. Proc. 25, 718 (1966); W. R. Buckett et al., Br. J. Pharmacol. Chemother. 32, 671 (1968); I. L. Bonta et al., Eur. J. Pharmacol. 4, 83, 303 (1968). Comparative study of neuromuscular blocking and vagolytic effect: S. L. Son et al., Anesthesiology 55, 12 (1981). Review: Speight, Avery, Drugs 4, 163-226 (1972).
Properties: Odorless crystals with bitter taste, mp 215°. One gram dissolves in 30 parts chloroform, one part water (20°). LD50 in mice (mg/kg): 0.047 i.v.; 0.152 i.p.; 0.167 s.c.; 21.9 orally; in rats, rabbits: 0.153, 0.016 i.v. (Buckett, 1968).
Melting point: mp 215°
Toxicity data: LD50 in mice (mg/kg): 0.047 i.v.; 0.152 i.p.; 0.167 s.c.; 21.9 orally; in rats, rabbits: 0.153, 0.016 i.v. (Buckett, 1968)
Therap-Cat: Neuromuscular blocking agent.
Therap-Cat-Vet: Neuromuscular blocking agent.
Keywords: Neuromuscular Blocking Agent; Nondepolarizing Agents.

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