Frangulin
Structural Formula Vector Image
Title: Frangulin
CAS Registry Number: 60529-33-1
Additional Names: Franguloside; avornin
Trademarks: Cascarin
Literature References: In berries, bark, and rootbark of Rhamnus spp., especially in alder buckthorn (Rhamnus frangula L.), Rhamnus carthartica L., and Rhamnus purshiana DC. (Cascara sagrada), Rhamnaceae. Prepn from bark of alder buckthorn: Bridel, Charaux, Bull. Soc. Chim. Biol. 15, 642 (1933); M. Kubiak, Herba Pol. 23, 217 (1977), C.A. 88, 166260b (1978). Consists of the two glucosides, frangulins A and B, which were originally thought to be isomeric. Structure and synthesis of frangulin A: Hörhammer, Wagner, Z. Naturforsch. 27B, 959 (1972). Structure of frangulin B: Wagner, Demuth, Tetrahedron Lett. 1972, 5013.
 
Derivative Type: Frangulin A
CAS Registry Number: 521-62-0
Additional Names: 1,3,8-Trihydroxy-6-methylanthraquinone-l-rhamnoside; emodin-l-rhamnoside; rhamnoxanthin
Molecular Formula: C21H20O9
Molecular Weight: 416.38
Percent Composition: C 60.58%, H 4.84%, O 34.58%
Properties: Crystals, mp 228°. Absorption max: 225, 264, 282, 300, 430 nm (log e 4.52, 4.28, 4.15, 3.97, 4.05).
Melting point: mp 228°
Absorption maximum: Absorption max: 225, 264, 282, 300, 430 nm (log e 4.52, 4.28, 4.15, 3.97, 4.05)
 
Derivative Type: Frangulin B
CAS Registry Number: 14101-04-3
Additional Names: 6-O-(D-Apiofuranosyl)-1,6,8-trihydroxy-3-methylanthraquinone
Molecular Formula: C20H18O9
Molecular Weight: 402.35
Percent Composition: C 59.70%, H 4.51%, O 35.79%
Properties: mp 196°.
Melting point: mp 196°
 
Therap-Cat: Cathartic.
Keywords: Laxative/Cathartic.

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