Butoctamide
Structural Formula Vector Image
Title: Butoctamide
CAS Registry Number: 32838-26-9
CAS Name: N-(2-Ethylhexyl)-3-hydroxybutanamide
Additional Names: N-(2-ethylhexyl)-3-hydroxybutyramide; hexobutyramide
Molecular Formula: C12H25NO2
Molecular Weight: 215.33
Percent Composition: C 66.93%, H 11.70%, N 6.50%, O 14.86%
Literature References: Prepn: A. Sakuma et al., FR 8393; eidem, US 3639457; eidem, JP Kokai 79 24822, C.A. 91, 34947f (1979) (1971, 1972, 1979 all to Lion Dentifrice). Toxicology study: M. Kato et al., Oyo Yakuri 17, 287 (1979), C.A. 91, 68665e (1979). Acute toxicity: R. Goshima et al., Toho Igakkai Zasshi 17, 579 (1970), C.A. 74, 138765n (1971). Clinical effect on rapid eye movement (REM) sleep: Y. Hayashi et al., Psychopharmacology 77, 367 (1982); in Down's syndrome: J. C. Grubar et al., ibid. 90, 119 (1986).
Properties: Colorless viscous oil, bp0.30 mm 149-150°.
Boiling point: bp0.30 mm 149-150°
 
Derivative Type: Hydrogen succinate
CAS Registry Number: 32838-28-1
Additional Names: Butanedioic acid mono[3-[(2-ethylhexyl)amino]-1-methyl-3-oxopropyl] ester; succinic acid monoester with N-(2-ethylhexyl)-3-hydroxybutyramide; N-2-ethylhexyl-b-oxybutyramide semisuccinate; BAHS
Manufacturers' Codes: M-2H
Trademarks: Listomin S (Lion)
Molecular Formula: C16H29NO5
Molecular Weight: 315.41
Percent Composition: C 60.93%, H 9.27%, N 4.44%, O 25.36%
Properties: Colorless viscous oil; mp 46.5°.
Melting point: mp 46.5°
 
Derivative Type: Hydrogen succinate calcium salt
CAS Registry Number: 32266-82-3
Molecular Formula: C32H58CaN2O10
Molecular Weight: 670.89
Percent Composition: C 57.29%, H 8.71%, Ca 5.97%, N 4.18%, O 23.85%
Properties: White powder, slightly hygroscopic. uv max: 192 (E1%1cm 290). LD50 in mice (mg/kg): 476 i.p.; 2000 orally (Sakuma, 1971).
Absorption maximum: uv max: 192 (E1%1cm 290)
Toxicity data: LD50 in mice (mg/kg): 476 i.p.; 2000 orally (Sakuma, 1971)
 
Therap-Cat: Sedative, hypnotic.
Keywords: Sedative/Hypnotic; Amides.
 
 
Status: This monograph has been retired and is no longer subject to revision or update.

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