Structural Formula Vector Image
Title: Brequinar
CAS Registry Number: 96187-53-0
CAS Name: 6-Fluoro-2-(2¢-fluoro[1,1¢-biphenyl]-4-yl)-3-methyl-4-quinolinecarboxylic acid
Molecular Formula: C23H15F2NO2
Molecular Weight: 375.37
Percent Composition: C 73.59%, H 4.03%, F 10.12%, N 3.73%, O 8.52%
Literature References: Inhibitor of dihydroorotate dehydrogenase, the fourth enzyme in the de novo pyrimidine biosynthetic pathway; depresses lymphocyte proliferation. Prepn: D. P. Hesson, EP 133244; idem, US 4680299 (1985, 1987 both to DuPont). Mechanisms of action: T. L. Forrest et al., Transplantation 58, 920 (1994). Clinical pharmacokinetics: M. de Forni et al., Eur. J. Cancer 29A, 983 (1993). Symposium on pharmacology, toxicology: Transplant. Proc. 25, Suppl. 2, 1-83 (1993). Review of development and clinical experience: L. Makowka et al., Immunol. Rev. 136, 51-70 (1993).
Properties: White crystals from DMF + water, mp 315-317°.
Melting point: mp 315-317°
Derivative Type: Sodium salt
CAS Registry Number: 96201-88-6
Manufacturers' Codes: DUP-785; NSC-368390
Molecular Formula: C23H14F2NNaO2
Molecular Weight: 397.35
Percent Composition: C 69.52%, H 3.55%, F 9.56%, N 3.53%, Na 5.79%, O 8.05%
Properties: White solid, mp >360°. Sol in water.
Melting point: mp >360°
Therap-Cat: Immunosuppressant.
Keywords: Immunosuppressant.

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