Structural Formula Vector Image
Title: Tripamide
CAS Registry Number: 73803-48-2
CAS Name: (3aa,4a,7a,7aa)-3-(Aminosulfonyl)-4-chloro-N-(octahydro-4,7-methano-2H-isoindol-2-yl)benzamide
Additional Names: 4-chloro-N-(endo-hexahydro-4,7-methanoisoindolin-2-yl)-3-sulfamoylbenzamide; toripamide
Manufacturers' Codes: ADR-033; E-614
Trademarks: Normonal (Eisai)
Molecular Formula: C16H20ClN3O3S
Molecular Weight: 369.87
Percent Composition: C 51.96%, H 5.45%, Cl 9.59%, N 11.36%, O 12.98%, S 8.67%
Literature References: Sulfonamide with diuretic and peripheral vasodilator activity. Prepn: H. Hamano et al., JP 73 5585 (1973 to Eisai), C.A. 78, 136070r (1973). Synthesis of 14C-tripamide: T. Nakamura et al., J. Labelled Compd. Radiopharm. 14, 191 (1978). Pharmacological study: T. Satoh et al., Oyo Yakuri 21, 607 (1981), C.A. 96, 28414u (1982). Metabolism: T. Horie et al., Xenobiotica 11, 197, 693 (1981).
Properties: Colorless needles.
Therap-Cat: Antihypertensive; diuretic.
Keywords: Antihypertensive; Sulfonamide Derivatives; Diuretic; Sulfonamide Derivatives.

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