Trioxsalen
Structural Formula Vector Image
Title: Trioxsalen
CAS Registry Number: 3902-71-4
CAS Name: 2,5,9-Trimethyl-7H-furo[3,2-g][1]benzopyran-7-one
Additional Names: 6-hydroxy-b,2,7-trimethyl-5-benzofuranacrylic acid d-lactone; 4,5¢,8-trimethylpsoralen
Manufacturers' Codes: NSC-71047
Trademarks: Trisoralen (Valeant)
Molecular Formula: C14H12O3
Molecular Weight: 228.24
Percent Composition: C 73.67%, H 5.30%, O 21.03%
Literature References: Synthetic trimethyl psoralen deriv. Prepn: K. D. Kaufman, J. Org. Chem. 26, 117 (1961); US 3201421 (1965). Protective effect vs UV-B erythema: P. G. Agache, L. Coupez, Arch. Dermatol. Res. 268, 85 (1980). Clinical study: N. Vaatainen et al., Clin. Exp. Dermatol. 6, 133 (1981). Comprehensive description: M. M. A. Hassan, M. A. Loutfy, Anal. Profiles Drug Subs. 10, 705-727 (1981). See also Psoralen, Methoxsalen.
Properties: Prisms from chloroform, mp 234.5-235°. uv max (methanol): 250, 295, 335 nm (log e 4.35, 3.99, 3.80). Sol in methylene chloride. Slightly sol in alc, chloroform. Practically insol in water.
Melting point: mp 234.5-235°
Absorption maximum: uv max (methanol): 250, 295, 335 nm (log e 4.35, 3.99, 3.80)
Therap-Cat: Pigmentation agent (photosensitizer).
Keywords: Pigmentation Agent.

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