Structural Formula Vector Image
Title: Thiazolsulfone
CAS Registry Number: 473-30-3
CAS Name: 5-[(4-Aminophenyl)sulfonyl]-2-thiazolamine
Additional Names: 2-amino-5-sulfanilylthiazole; 4-aminophenyl-2¢-aminothiazolyl-5¢-sulfone; thiazosulfone; thiazolesulfone
Trademarks: Promizole (Parke-Davis)
Molecular Formula: C9H9N3O2S2
Molecular Weight: 255.32
Percent Composition: C 42.34%, H 3.55%, N 16.46%, O 12.53%, S 25.12%
Literature References: Prepd from the reaction products of p-nitrobenzenesulfonyl chloride and 2 mols of 2-aminothiazole: Bambas, J. Am. Chem. Soc. 67, 671 (1945); Bambas, US 2389126 (1945 to Parke, Davis).
Properties: Fine needles from alc, mp 219-221° (some decompn). Sol in water at pH 6.5 to the extent of 30-40 mg per 100 ml at 28-30°. Freely sol in acetone, dioxane, 70% alc, dil acids. Moderately sol in abs alcohol, ethyl acetate and ether. It is a very weak acid, dissolves in 10% alkali (decompn) and forms an alkali metal salt at pH 10.
Melting point: mp 219-221° (some decompn)
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Synthetic); Sulfones.

Other Monographs:
Hydracrylic AcidTriclabendazoleQuizalofop-ethylSodium Cyanide
Isosorbide DinitrateHeptachlorTrilliumCadherins
©2006-2023 DrugFuture->Chemical Index Database