Structural Formula Vector Image
Title: Tetraconazole
CAS Registry Number: 112281-77-3
CAS Name: 1-[2-(2,4-Dichlorophenyl)-3-(1,1,2,2-tetrafluoroethoxy)propyl]-1H-1,2,4-triazole
Additional Names: (RS)-2-(2,4-dichlorophenyl)-3-(1H-1,2,4-triazol-1-yl)propyl 1,1,2,2-tetrafluoroethyl ether
Manufacturers' Codes: M-14360
Trademarks: Domark (Isagro); Eminent (Isagro); Lospel (Isagro)
Molecular Formula: C13H11Cl2F4N3O
Molecular Weight: 372.15
Percent Composition: C 41.96%, H 2.98%, Cl 19.05%, F 20.42%, N 11.29%, O 4.30%
Literature References: Systemic triazole antifungal; inhibitor of sterol biosynthesis. Prepn: JP Kokai 87 169773; R. Colle et al., US 5081141 (1987, 1992 both to Montedison). Chemical and biological properties: C. Garavaglia et al., Brighton Crop Prot. Conf. - Pests Dis. 1988, 49. Chemoenzymatic stereospecific synthesis and biological activity of racemate and enantiomers: D. Bianchi et al., J. Agric. Food Chem. 39, 197 (1991); stereoselective inhibition of ergosterol biosynthesis: F. Gozzo et al., Pestic. Biochem. Physiol. 53, 10 (1995). ELISA of commercial prepns: F. Forlani et al., J. Agric. Food Chem. 40, 328 (1992). Field trial on wheat: D. Pancaldi, I. Alberti, Informat. Fitopatolog. 44, 48 (1994).
Properties: Viscous colorless oil. Vapor pressure (20°): 1.2´ 10-5 mmHg. Log P (octan-1-ol/water): 3.1 (pH 7). Stable in dil. aq. soln at pH 5-9. Stable in sunlight. Soly (20°) mg/l: water 150. Readily sol in dichloromethane, acetone and methanol. LD50 orally in rats: 1150 mg/kg (Garavaglia).
Log P: Log P (octan-1-ol/water): 3.1 (pH 7)
Toxicity data: LD50 orally in rats: 1150 mg/kg (Garavaglia)
Use: Agricultural fungicide.

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