Structural Formula Vector Image
Title: Tasosartan
CAS Registry Number: 145733-36-4
CAS Name: 5,8-Dihydro-2,4-dimethyl-8-[[2¢-(1H-tetrazol-5-yl)[1,1¢-biphenyl]-4-yl]methyl]pyrido[2,3-d]pyrimidin-7(6H)-one
Manufacturers' Codes: ANA-756
Trademarks: Verdia (Am. Home)
Molecular Formula: C23H21N7O
Molecular Weight: 411.46
Percent Composition: C 67.14%, H 5.14%, N 23.83%, O 3.89%
Literature References: Selective angiotensin II type 1 (AII1)-receptor antagonist. Prepn: J. W. Ellingboe et al., US 5149699 (1992 to Am. Home); idem et al., J. Med. Chem. 37, 542 (1994). Clinical tolerability in patients with essential hypertension: S. Oparil et al., Curr. Ther. Res. 58, 930 (1997); and efficacy: J. M. Neutel et al., Am. Heart J. 137, 118 (1999).
Properties: White crystals from ethanol, mp 197-199°.
Melting point: mp 197-199°
Therap-Cat: Antihypertensive.
Keywords: Angiotensin II Receptor Antagonist; Antihypertensive; Biphenyltetrazole Derivatives.
Status: This monograph has been retired and is no longer subject to revision or update.

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