Structural Formula Vector Image
Title: Succimer
CAS Registry Number: 304-55-2
CAS Name: (2R,3S)-rel-2,3-Dimercaptobutanedioic acid
Additional Names: meso-2,3-dimercaptosuccinic acid; DMS; DMSA
Manufacturers' Codes: Ro-1-7977
Trademarks: Chemet (McNeil)
Molecular Formula: C4H6O4S2
Molecular Weight: 182.22
Percent Composition: C 26.37%, H 3.32%, O 35.12%, S 35.19%
Literature References: A water soluble chelating agent. Prepn: L. N. Owen, M. U. S. Sultanbawa, J. Chem. Soc. 1949, 3109. Pharmacology, toxicity and activity in heavy metal poisoning in animals: E. Friedheim, C. Corvi, J. Pharm. Pharmacol. 27, 624 (1975); J. H. Graziano et al., J. Pharmacol. Exp. Ther. 207, 1051 (1978). GC determn in urine: J. J. Knudsen, E. L. McGown, J. Chromatogr. 424, 231 (1988). Clinical evaluations in heavy metal poisoning: E. Friedheim et al., Lancet 2, 1234 (1978); L. Fournier et al., Med. Toxicol. 3, 499 (1988). Diagnostic use of complex with technetium in urinary tract imaging: I. G. Verber et al., Arch. Dis. Child. 63, 1320 (1988); in tumor imaging: H. Ohta et al., Nucl. Med. Commun. 9, 105 (1988). Review: H. V. Aposhian, "Biological Chelation: 2,3-Dimercaptopropanesulfonic Acid and Meso-Dimercaptosuccinic Acid" in Adv. Enzyme Regul. 20, G. Weber, Ed. (Pergamon Press, Oxford, 1982) pp 301-319. Review of pharmacology and clinical use in heavy metal poisoning: idem, Annu. Rev. Pharmacol. Toxicol. 23, 193-215 (1983); J. H. Graziano, Med. Toxicol. 1, 155-162 (1986).
Properties: White crystals from aqueous methanol, mp 192-194°. LD50 i.p. in mice: >3000 mg/kg (Friedheim, Corvi).
Melting point: mp 192-194°
Toxicity data: LD50 i.p. in mice: >3000 mg/kg (Friedheim, Corvi)
Use: Chelating agent.
Therap-Cat: Antidote (heavy metal poisoning). 99mTc complex as diagnostic aid (radioactive imaging agent).
Keywords: Antidote (Heavy Metal Poisoning); Chelating Agent.

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