Structural Formula Vector Image
Title: Rolicyprine
CAS Registry Number: 2829-19-8
CAS Name: 5-Oxo-N-(2-phenylcyclopropyl)-2-pyrrolidinecarboxamide
Additional Names: D-N-(trans-2-phenylcyclopropyl)-L-5-pyrrolidone-2-carboxamide; rolicypram
Manufacturers' Codes: EX-4883; RMI-83027
Molecular Formula: C14H16N2O2
Molecular Weight: 244.29
Percent Composition: C 68.83%, H 6.60%, N 11.47%, O 13.10%
Literature References: Prepn: (isomer obtained not specified) GB 961313 (1964 to Lakeside Labs.); GB 1000895 (1965 to Colgate-Palmolive); Biel, US 3192229 (1965 to Colgate-Palmolive). Prepn of other stereoisomers: Biel, loc. cit. Toxicity study: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971).
Properties: Crystals from water, mp 144-147°. [a]D25 +104.28° (DMF). LD50 orally in rats: 96±8 mg/kg (Goldenthal).
Melting point: mp 144-147°
Optical Rotation: [a]D25 +104.28° (DMF)
Toxicity data: LD50 orally in rats: 96±8 mg/kg (Goldenthal)
Therap-Cat: Antidepressant.
Keywords: Antidepressant; Pyrrolidones.
Status: This monograph has been retired and is no longer subject to revision or update.

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