Prednisolone 21-Diethylaminoacetate
Structural Formula Vector Image
Title: Prednisolone 21-Diethylaminoacetate
CAS Registry Number: 5626-34-6
CAS Name: N,N-Diethylglycine (11b)-11,17-dihydroxy-3,20-dioxopregna-1,4-dien-21-yl ester
Additional Names: 11b,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-(N,N-diethylglycine) ester; prednisolone 21-N,N-diethylglycinate; prednisolamate
Molecular Formula: C27H39NO6
Molecular Weight: 473.60
Percent Composition: C 68.47%, H 8.30%, N 2.96%, O 20.27%
Literature References: Prepd from prednisolone and N,N-diethylaminoacetyl chloride hydrochloride: Pancrazio, Sbarigia, Farmaco Ed. Prat. 16, 190 (1961); from prednisolone and chloroacetyl chloride followed by reaction with diethylamine: GB 862370 (1961 to Pfizer).
Properties: Crystals from acetone + hexane, mp 175-177°.
Melting point: mp 175-177°
 
Derivative Type: Hydrochloride
CAS Registry Number: 17140-01-1
Trademarks: Deltacortril DA
Molecular Formula: C27H39NO6.HCl
Molecular Weight: 510.06
Percent Composition: C 63.58%, H 7.90%, N 2.75%, O 18.82%, Cl 6.95%
Properties: Crystals from ethanol, mp 237.4-239.8°. [a]D +120.7° (water).
Melting point: mp 237.4-239.8°
Optical Rotation: [a]D +120.7° (water)
 
Therap-Cat: Glucocorticoid.
Keywords: Glucocorticoid.
 
 
Status: This monograph has been retired and is no longer subject to revision or update.

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