Structural Formula Vector Image
Title: Phenoxybenzamine
CAS Registry Number: 59-96-1
CAS Name: N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzenemethanamine
Additional Names: N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine; N-phenoxyisopropyl-N-benzyl-b-chloroethylamine; bensylyt
Manufacturers' Codes: 688-A
Molecular Formula: C18H22ClNO
Molecular Weight: 303.83
Percent Composition: C 71.16%, H 7.30%, Cl 11.67%, N 4.61%, O 5.27%
Literature References: Prepn: Kerwin, Ullyot, US 2599000 (1952 to SK&F).
Properties: Crystals from petr ether, mp 38-40°. Sol in benzene.
Melting point: mp 38-40°
Derivative Type: Hydrochloride
CAS Registry Number: 63-92-3
Trademarks: Dibenyline (SKB); Dibenzyline (SKB); Dibenzyran (Procter & Gamble)
Molecular Formula: C18H22ClNO.HCl
Molecular Weight: 340.29
Percent Composition: C 63.53%, H 6.81%, Cl 20.84%, N 4.12%, O 4.70%
Properties: Crystals from alcohol + ether, mp 137.5-140°. Sol in alcohol, propylene glycol. Very sparingly sol in water. Solutions in propylene glycol should be sterilized by filtration.
Melting point: mp 137.5-140°
CAUTION: Phenoxybenzamine hydrochloride is reasonably anticipated to be a human carcinogen: Report on Carcinogens, Eleventh Edition (PB2005-104914, 2004) p III-216.
Therap-Cat: Antihypertensive.
Keywords: Antipheochromocytoma.

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