Structural Formula Vector Image
Title: Phenamidine
CAS Registry Number: 101-62-2
CAS Name: 4,4¢-Oxybisbenzenecarboximidamide
Additional Names: 4,4¢-oxydibenzamidine; 4,4¢-diamidinodiphenyl ether
Molecular Formula: C14H14N4O
Molecular Weight: 254.29
Percent Composition: C 66.13%, H 5.55%, N 22.03%, O 6.29%
Literature References: Prepn: A. J. Ewins et al., GB 507565 (1939 to May & Baker); J. N. Ashley et al., J. Chem. Soc. 1942, 103; of isethionate: G. Newbery, A. P. T. Easson, US 2410796 (1946 to May & Baker). Trypanocidal activity: E. M. Lourie, W. Yorke, Ann. Trop. Med. Parasitol. 33, 289 (1939). Preliminary pharmacology: R. Wien, ibid. 37, 1 (1943). Use in treatment of Babesia infections in dogs: M. D. Ruff et al., Am. J. Vet. Res. 34, 641 (1973); R. Gothe et al., Kleintier-Praxis 32, 97 (1987). Early review of pharmacology, mode of action and clinical applications: E. M. Schoenbach, E. M. Greenspan, Medicine 27, 327-377 (1948).
Properties: Irregular plates from water, mp 215-216°.
Melting point: mp 215-216°
Derivative Type: Isethionate
CAS Registry Number: 620-90-6
Manufacturers' Codes: M & B 736
Trademarks: Lomadine (M & B)
Molecular Formula: C14H14N4O.2C2H6O4S
Molecular Weight: 506.55
Percent Composition: C 42.68%, H 5.17%, N 11.06%, O 28.43%, S 12.66%
Properties: Crystals, mp 225° (dec). One part is sol in 1.4 parts water; 300 parts alcohol. Practically insol in ether, chloroform.
Melting point: mp 225° (dec)
Therap-Cat-Vet: Antiprotozoal (Babesia).

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