Structural Formula Vector Image
Title: Parvaquone
CAS Registry Number: 4042-30-2
CAS Name: 2-Cyclohexyl-3-hydroxy-1,4-naphthalenedione
Additional Names: 2-cyclohexyl-3-hydroxy-1,4-naphthoquinone; 2-hydroxy-3-cyclohexyl-1,4-naphthoquinone
Manufacturers' Codes: BW-993C
Trademarks: Clexon (Wellcome)
Molecular Formula: C16H16O3
Molecular Weight: 256.30
Percent Composition: C 74.98%, H 6.29%, O 18.73%
Literature References: Prepn: L. F. Fieser, J. Am. Chem. Soc. 70, 3165 (1948); L. F. Fieser, M. T. Leffler, US 2553648 (1951 to Research Corp.). Antimalarial activity: L. F. Fieser, A. P. Richardson, J. Am. Chem. Soc. 70, 3156 (1948). Electron transport inhibition: A. L. Tappel, Biochem. Pharmacol. 3, 289 (1960); by uncoupling: J. L. Howland, Biochim. Biophys. Acta 131, 247 (1967). In vitro and in vivo antiprotozoal activity: A. T. Hudson et al., Parasitology 90, 45 (1985). Bioassay in serum: N. McHardy, J. Mercer, Kenya Vet. 8(2), 9 (1984). Treatment of East Coast fever in cattle: T. T. Dolan et al., Vet. Parasitol. 15, 103 (1984); of Theileria annulata in calves: N. McHardy, D. W. Morgan, Res. Vet. Sci. 39, 1 (1985). Field comparison of antitheilarial activity with buparvaquone, q.v.: N. McHardy et al., ibid. 39.
Properties: Bright yellow needles, mp 135-136°.
Melting point: mp 135-136°
Therap-Cat-Vet: Antiprotozoal (Theileria).

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