Structural Formula Vector Image
Title: Pamaquine
CAS Registry Number: 491-92-9
CAS Name: N1,N1-Diethyl-N4-(6-methoxy-8-quinolinyl)-1,4-pentanediamine
Additional Names: 8-[[4-(diethylamino)-1-methylbutyl]amino]-6-methoxyquinoline
Molecular Formula: C19H29N3O
Molecular Weight: 315.45
Percent Composition: C 72.34%, H 9.27%, N 13.32%, O 5.07%
Literature References: Prepn: GB 295656 (1927 to I. G. Farbenind); K. H. Slotta, Grundriss der modernen Arzneistoff-Synthese (Stuttgart, 1931); Elderfield et al., J. Am. Chem. Soc. 70, 40 (1948). Review: Cooper, Public Health Rep. 64, 717 (1949). HPLC determn in plasma: Y. S. Endoh et al., J. Chromatogr. 579, 123 (1992). Historical review: D. Greenwoood, J. Antimicrob. Chemother. 36, 857-872 (1995).
Properties: Dark yellow oil. bp0.3 175-180°; bp1 182-194°.
Boiling point: bp0.3 175-180°; bp1 182-194°
Derivative Type: Pamoate
CAS Registry Number: 635-05-2
Additional Names: Pamaquine embonate; pamaquine naphthoate
Trademarks: Aminoquin; Plasmochin; Plasmoquine; Praequine
Molecular Formula: C19H29N3O.C23H16O6
Molecular Weight: 703.82
Percent Composition: C 71.67%, H 6.44%, N 5.97%, O 15.91%
Properties: Yellow to orange-yellow odorless, almost tasteless powder. Numbs the tongue. Insol in water. Sol in alcohol, acetone. Protect from light.
Therap-Cat: Antimalarial.
Keywords: Antimalarial.

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