Oxitropium Bromide
Structural Formula Vector Image
Title: Oxitropium Bromide
CAS Registry Number: 30286-75-0
CAS Name: [7(S)-(1a,2b,4b,5a,7b)]-9-Ethyl-7-(3-hydroxy-1-oxo-2-phenylpropoxy)-9-methyl-3-oxa-9-azoniatricyclo[,4]nonane bromide
Additional Names: (8r)-6b,7b-epoxy-8-ethyl-3a-hydroxy-1aH,5aH-tropanium bromide (-)-tropate; (-)-N-ethylnorscopolamine methobromide
Manufacturers' Codes: Ba-253; Ba-253-BR-L
Trademarks: Oxivent (Boehringer, Ing.); Tersigat (Boehringer, Ing.); Ventilat (Thomae)
Molecular Formula: C19H26BrNO4
Molecular Weight: 412.32
Percent Composition: C 55.35%, H 6.36%, Br 19.38%, N 3.40%, O 15.52%
Literature References: Anticholinergic bronchodilating agent. Prepn: K. Zeile et al., US 3472861 (1969 to Boehringer, Ing.). Comparison with fenoterol, q.v.: D. Nolte, Respiration 36, 32 (1978); with ipratropium bromide, q.v.: J. Lulling et al., ibid. 42, 188 (1981). Efficacy in bronchial asthma: H. M. Beumer et al., Int. J. Clin. Pharmacol. Ther. Toxicol. 19, 168 (1981); in exercise-induced asthma: K. Larsson, Respiration 43, 57 (1982).
Properties: Crystals, mp 203-204° (dec). [a]D21 -25° (c = 2.0 in water).
Melting point: mp 203-204° (dec)
Optical Rotation: [a]D21 -25° (c = 2.0 in water)
Therap-Cat: Bronchodilator.
Keywords: Bronchodilator; Quaternary Ammonium Compounds; Antimuscarinic.

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