Structural Formula Vector Image
Title: Nebracetam
CAS Registry Number: 97205-34-0
CAS Name: 4-(Aminomethyl)-1-(phenylmethyl)-2-pyrrolidinone
Additional Names: (±)-4-(aminomethyl)-1-benzyl-2-pyrrolidinone
Manufacturers' Codes: WEB-1881
Molecular Formula: C12H16N2O
Molecular Weight: 204.27
Percent Composition: C 70.56%, H 7.89%, N 13.71%, O 7.83%
Literature References: Cognition enhancer with cholinergic and cytoprotectant activity. Prepn: K. H. Weber et al., DE 3336024; eidem, US 4833140 (1985, 1989, both to Boehringer, Ing.). Pharmacology: F. J. Kuhn et al., Arch. Int. Pharmacodyn. Ther. 292, 13 (1988). Toxicology: T. Yabe et al., Oyo Yakuri 44, 417 (1992), C.A. 117, 245471s (1992). Clinical effect on cognitive processes: T. F. Münte et al., Neuropsychobiology 19, 158 (1988). Clinical evaluation in Alzheimer's disease: K. Urakami et al., Clin. Neuropharmacol. 16, 347 (1993).
Derivative Type: Fumarate
CAS Registry Number: 97205-35-1
Manufacturers' Codes: WEB-1881FU
Molecular Formula: (C12H16N2O)2.C4H4O4
Molecular Weight: 524.61
Percent Composition: C 64.10%, H 6.92%, N 10.68%, O 18.30%
Properties: Crystals, mp 192-194°. LD50 in male, female rats (mg/kg): 257, 257 i.v.; 2884, 3622 orally (Yabe).
Melting point: mp 192-194°
Toxicity data: LD50 in male, female rats (mg/kg): 257, 257 i.v.; 2884, 3622 orally (Yabe)
Therap-Cat: Nootropic.
Keywords: Nootropic.
Status: This monograph has been retired and is no longer subject to revision or update.

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