Medrogestone
Structural Formula Vector Image
Title: Medrogestone
CAS Registry Number: 977-79-7
CAS Name: 6,17-Dimethylpregna-4,6-diene-3,20-dione
Additional Names: 6,17a-dimethyl-6-dehydroprogesterone
Manufacturers' Codes: AY-62022
Trademarks: Colpro (Dagra); Colprone (Ayerst); Prothil (Kali-Chemie)
Molecular Formula: C23H32O2
Molecular Weight: 340.50
Percent Composition: C 81.13%, H 9.47%, O 9.40%
Literature References: Prepn: Deghenghi, Gaudry, J. Am. Chem. Soc. 83, 4668 (1961); Deghenghi et al., Tetrahedron 19, 289 (1963); J. Med. Chem. 6, 301 (1963); Deghenghi, US 3133913, US 3210387; Morand, Deghenghi, US 3170936 (1964, 1965, and 1965, all to Am. Home Prod.). HPLC determn in serum: W. T. Robinson, L. Cosyns, Arzneim.-Forsch. 29, 882 (1979). Comparative clinical evaluation in benign prostatic hyperplasia: D. F. Paulson, R. D. Kane, J. Urol. 113, 811 (1975); in endometrial carcinoma: K. C. Podratz et al., Obstet. Gynecol. 66, 106 (1985).
Properties: Crystals from ether, mp 144-146°. [a]D23 +79° (c = 1 in chloroform). uv max: 288 nm (e 25000).
Melting point: mp 144-146°
Optical Rotation: [a]D23 +79° (c = 1 in chloroform)
Absorption maximum: uv max: 288 nm (e 25000)
Therap-Cat: Progestogen.
Keywords: Progestogen.

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