Structural Formula Vector Image
Title: Lidofenin
CAS Registry Number: 59160-29-1
CAS Name: N-(Carboxymethyl)-N-[2-[(2,6-dimethylphenyl)amino]-2-oxoethyl]glycine
Additional Names: N-(2,6-dimethylacetanilide)iminodiacetic acid; N-(2,6-dimethylphenylcarbamoylmethyl)iminodiacetic acid; [[(2,6-xylylcarbamoyl)methyl]imino]diacetic acid; HIDA
Molecular Formula: C14H18N2O5
Molecular Weight: 294.30
Percent Composition: C 57.14%, H 6.16%, N 9.52%, O 27.18%
Literature References: Iminodiacetic acid analog. Prepn of compd and 99mTc-complex: M. D. Loberg et al., BE 840556; eidem, US 4017596 (1976, 1977 both to Research Corp.); and imaging studies: M. D. Loberg et al., J. Nucl. Med. 17, 633 (1976). Structural studies: M. D. Loberg, A. T. Fields, Int. J. Appl. Radiat. Isot. 29, 167 (1978). Chromatographic determn of radiochemical purity: A. M. Zimmer et al., Eur. J. Nucl. Med. 7, 88 (1982). Biodistribution and clinical kinetics: J. Ryan et al., J. Nucl. Med. 18, 995 (1977). Clinical studies of diagnostic use as hepatobiliary imaging agent: H. S. Weissmann et al., Am. J. Roentgenol. 132, 523 (1979); R. W. Nicholson et al., Br. J. Radiol. 53, 878 (1980).
Properties: Crystals from water, mp 201-203°. LD50 i.v. in male mice: 168 mg/kg (Ryan).
Melting point: mp 201-203°
Toxicity data: LD50 i.v. in male mice: 168 mg/kg (Ryan)
Derivative Type: 99mTc-complex
Additional Names: 99mTc-HIDA
Trademarks: TechneScan HIDA (Mallinckrodt)
Therap-Cat: 99mTc-complex as diagnostic aid (radioactive imaging agent).

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