Structural Formula Vector Image
Title: Isopromethazine
CAS Registry Number: 303-14-0
CAS Name: N,N,b-Trimethyl-10H-phenothiazine-10-ethanamine
Additional Names: 10-(2-dimethylamino-1-methylethyl)phenothiazine; 10-(2-dimethylaminoisopropyl)phenothiazine; isomethazine
Manufacturers' Codes: Lilly 01526; RP-4460
Trademarks: Isophenergan; Fen-Bridal
Molecular Formula: C17H20N2S
Molecular Weight: 284.42
Percent Composition: C 71.79%, H 7.09%, N 9.85%, S 11.27%
Literature References: Prepn: Charpentier, Compt. Rend. 225, 306 (1947); Charpentier, Ducrot, ibid. 232, 415 (1951); Charpentier et al., ibid. 2232; Berg, Ashley, US 2607773 (1952 to Rhône-Poulenc); Edge, Wragg, J. Pharm. Pharmacol. 5, 279 (1953).
Derivative Type: Hydrochloride
Additional Names: Diprazin
Molecular Formula: C17H20N2S.HCl
Molecular Weight: 320.88
Percent Composition: C 63.63%, H 6.60%, N 8.73%, S 9.99%, Cl 11.05%
Properties: Crystals, mp 193-194°. More sol than promethazine.
Melting point: mp 193-194°
Therap-Cat: Antihistaminic.
Keywords: Antihistaminic; Tricyclics; Phenothiazines.
Status: This monograph has been retired and is no longer subject to revision or update.

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