Glucosulfone Sodium
Structural Formula Vector Image
Title: Glucosulfone Sodium
CAS Registry Number: 554-18-7
CAS Name: 1,1¢-[Sulfonylbis(4,1-phenyleneimino)]bis[1-deoxy-1-sulfo-D-glucitol] disodium salt
Additional Names: p,p¢-sulfonyldianiline N,N¢-diglucoside disodium disulfonate; p,p¢-sulfonyldianiline-N,N¢-di-D-glucose sodium bisulfite compd; p,p¢-diaminodiphenylsulfone-N,N¢-di(dextrose sodium sulfonate); disodium p,p¢-diaminodiphenylsulfone-N,N¢-diglucose sulfonate
Manufacturers' Codes: 501-P
Trademarks: Protomin; Promin (Parke-Davis); Promanide
Molecular Formula: C24H34N2Na2O18S3
Molecular Weight: 780.70
Percent Composition: C 36.92%, H 4.39%, N 3.59%, Na 5.89%, O 36.89%, S 12.32%
Literature References: Prepd by refluxing a mixture of 4,4¢-diaminodiphenylsulfone, glucose, sodium bisulfite, and 80% ethanol: CH 234108 (1944 to B. Siegfried), C.A. 43, 4297a (1949); B. C. Jain et al., Sci. Cult. 11, 568 (1946). Structure activity study: W. Logemann, G. P. Miori, Arzneim.-Forsch. 5, 213 (1955). Clinical evaluation in ocular leprosy: A. Bouzas, Arch. Ophthalmol. 31, 629 (1971).
Properties: White, amorphous powder. Soluble in water; slightly sol in ethanol. Insol in ether, benzene, methanol, ethyl acetate, pyridine. Aq solns may be sterilized by autoclaving. LD50 in rats (g/kg): 3-4 orally, 3-3.5 i.v. (Logemann, Miori).
Toxicity data: LD50 in rats (g/kg): 3-4 orally, 3-3.5 i.v. (Logemann, Miori)
Therap-Cat: Antibacterial (leprostatic).
Keywords: Antibacterial (Synthetic); Sulfones; Antibacterial (Leprostatic).

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