Structural Formula Vector Image
Title: Dienestrol
CAS Registry Number: 84-17-3
CAS Name: 4,4¢-(1,2-Diethylidene-1,2-ethanediyl)bisphenol
Additional Names: 4,4¢-(diethylideneethylene)diphenol; 3,4-bis(p-hydroxyphenyl)-2,4-hexadiene; 4,4¢-dihydroxy-g,d-diphenyl-b,d-hexadiene; di(p-oxyphenyl)-2,4-hexadiene; dienoestrol; estrodienol
Trademarks: Cycladiene (Bruneau); Dienol; Dinovex (Ortho); DV (HMR); Estroral; Gynefollin; Hormofemin (Medo); Oestrasid; Oestrodiene; Oestroral; Restrol (Central Pharm.); Retalon; Synestrol (Schering)
Molecular Formula: C18H18O2
Molecular Weight: 266.33
Percent Composition: C 81.17%, H 6.81%, O 12.01%
Literature References: Synthesis: Dodds et al., Proc. Roy. Soc. 127B, 162 (1939); Hobday, Short, J. Chem. Soc. 1943, 609; Short, Hobday, US 2464203 (1949 to Boots); Adler, US 2465505 (1949 to Hoffmann-La Roche). Configuration: Koch, Nature 161, 309 (1948); Lane, Spialter, J. Am. Chem. Soc. 73, 4408 (1951).
Properties: Minute needles from dil alcohol, mp 227-228°. Sublimes at 130° and 1 mm Hg. The sublimate mp 231-234°. Freely sol in alcohol, methanol, ether, acetone, propylene glycol; sol in chloroform, aq solns of alkali hydroxides; sol in vegetable oils after warming, but crystallizes out on standing. Practically insol in water, dil acids.
Melting point: mp 227-228°; mp 231-234°
Derivative Type: Diacetate
CAS Registry Number: 84-19-5
Trademarks: Lipamone; Retalon-Oral
Molecular Formula: C22H22O4
Molecular Weight: 350.41
Percent Composition: C 75.41%, H 6.33%, O 18.26%
Properties: Prisms from alc, mp 119-120°.
Melting point: mp 119-120°
Therap-Cat: Estrogen.
Therap-Cat-Vet: Estrogenic hormone therapy.
Keywords: Estrogen; Nonsteroidal.

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