Dibutoline Sulfate
Structural Formula Vector Image
Title: Dibutoline Sulfate
CAS Registry Number: 532-49-0
CAS Name: 2-[[(Dibutylamino)carbonyl]oxy]-N-ethyl-N,N-dimethylethanaminium sulfate (2:1)
Additional Names: bis[ethyl(2-hydroxyethyl)dimethylammonium] sulfate bis(dibutylcarbamate); (2-dibutyl-carbamyloxyethyl)dimethylethylammonium sulfate; dimethylethyl-b-hydroxyethylammonium sulfate dibutylurethan
Trademarks: Dibuline Sulfate (Merck & Co.)
Molecular Formula: C30H66N4O8S
Molecular Weight: 642.93
Percent Composition: C 56.04%, H 10.35%, N 8.71%, O 19.91%, S 4.99%
Literature References: Anticholinergic. Prepd by treating dibutoline iodide with Ag2SO4: Swan, White, US 2408893 (1946); US 2432049 (1947).
Properties: Extremely hygroscopic powder. Dec 166°. Usually furnished as a colorless aqueous soln. Also sol in benzene. A surface-active agent; a 5% aq soln (pH 6.75-7.50) has an air-water interfacial tension of 42 dynes/cm at 25°; also reported as 47 dynes/cm: Swan, White, Am. J. Ophthalmol. 27, 933 (1944). Ampuled aq solns may be stored at room temp for at least one year without precipitation, darkening, change of pH, or loss of potency. Heating of aq solns at 100° causes decompn. Sterilization by filtration is recommended.
Therap-Cat: Antispasmodic.
Status: This monograph has been retired and is no longer subject to revision or update.

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