Structural Formula Vector Image
Title: Dapoxetine
CAS Registry Number: 119356-77-3
CAS Name: (aS)-N,N-Dimethyl-a-[2-(1-naphthalenyloxy)ethyl]benzenemethanamine
Additional Names: (+)-N,N-dimethyl-1-phenyl-3-(1-naphthalenyloxy)propanamine
Manufacturers' Codes: LY-210448
Molecular Formula: C21H23NO
Molecular Weight: 305.41
Percent Composition: C 82.59%, H 7.59%, N 4.59%, O 5.24%
Literature References: Selective serotonin reuptake inhibitor (SSRI). Prepn: D. W. Robertson et al., EP 288188; eidem, US 5135947 (1988, 1992 both to Lilly). Chiral synthesis: W. J. Wheeler, D. D. O'Bannon, J. Labelled Compd. Radiopharm. 31, 305 (1992). HPLC determn in plasma: C. L. Hamilton, J. D. Cornpropst, J. Chromatogr. 612, 253 (1993). Review of pharmacology and clinical experience: B. Feret, Formulary 40, 227-230 (2005).
Derivative Type: Hydrochloride
CAS Registry Number: 129938-20-1
Molecular Formula: C21H23NO.HCl
Molecular Weight: 341.87
Percent Composition: C 73.78%, H 7.08%, N 4.10%, O 4.68%, Cl 10.37%
Properties: White crystalline solid from hydrochloric acid and ethyl acetate. [a]D +135.78° (c = 2.18 in methanol).
Optical Rotation: [a]D +135.78° (c = 2.18 in methanol)
Therap-Cat: In treatment of premature ejaculation.
Keywords: Serotonin Uptake Inhibitor.

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