Structural Formula Vector Image
Title: Chlorphenoxamide
CAS Registry Number: 3576-64-5
CAS Name: 2,2-Dichloro-N-(2-hydroxyethyl)-N-[[4-(4-nitrophenoxy)phenyl]methyl]acetamide
Additional Names: N-(b-hydroxyethyl)-N-[p-(4-nitrophenoxy)benzyl]dichloroacetamide; N-(b-hydroxyethyl)-N-[p-phenoxy-(4¢-nitro)benzyl]dichloroacetamide; dichloro-N-(b-hydroxyethyl)-N-[p-(4¢-nitrophenoxy)benzyl]acetamide; clefamide; chlorophenoxamide
Trademarks: Mebinol (Erba)
Molecular Formula: C17H16Cl2N2O5
Molecular Weight: 399.23
Percent Composition: C 51.14%, H 4.04%, Cl 17.76%, N 7.02%, O 20.04%
Literature References: Prepn: Logemann et al., Farmaco Ed. Sci. 13, 139 (1958); US 2824894 (1958 to Carlo Erba). Antiamebic activity and toxicity data: Carneri, G. Mal. Infett. Parassit. 10, 850 (1958), C.A. 53, 5519C (1959).
Properties: Crystals from 95% ethanol, mp 136-137°. Practically insol in water (soly ~3 g/ml). Sol in ethanol, acetone, dioxane. LD50 in mice (mg/kg): >5000 orally, 2000 i.p. (Carneri).
Melting point: mp 136-137°
Toxicity data: LD50 in mice (mg/kg): >5000 orally, 2000 i.p. (Carneri)
NOTE: Do not confuse with chlorphenoxamine.
Therap-Cat: Antiamebic.
Keywords: Antiamebic.
Status: This monograph has been retired and is no longer subject to revision or update.

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