Structural Formula Vector Image
Title: Cyclopenthiazide
CAS Registry Number: 742-20-1
CAS Name: 6-Chloro-3-(cyclopentylmethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
Additional Names: 6-chloro-3-cyclopentylmethyl-3,4-dihydro-7-sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-dioxide; 3-cyclopentylmethyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide; cyclomethiazide; tsiklometiazid
Manufacturers' Codes: Su-8341
Trademarks: Navidrex (Goldshield); Salimid
Molecular Formula: C13H18ClN3O4S2
Molecular Weight: 379.88
Percent Composition: C 41.10%, H 4.78%, Cl 9.33%, N 11.06%, O 16.85%, S 16.88%
Literature References: Prepn: Whitehead et al., J. Org. Chem. 26, 2814 (1961); BE 587225 (1960 to Ciba). Pharmacology: W. E. Barrett et al., Arch. Int. Pharmacodyn. 131, 325 (1961).
Properties: Crystals from dil alc, mp 230°. LD50 in rats, mice (mg/kg): 141.8 ±24, 232.4 ±25 i.v. (Barrett).
Melting point: mp 230°
Toxicity data: LD50 in rats, mice (mg/kg): 141.8 ±24, 232.4 ±25 i.v. (Barrett)
Therap-Cat: Antihypertensive.
Keywords: Antihypertensive; Thiazides and Analogs; Diuretic; Thiazides and Analogs.

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