Structural Formula Vector Image
Title: Cyclobutyrol
CAS Registry Number: 512-16-3
CAS Name: a-Ethyl-1-hydroxycyclohexaneacetic acid
Additional Names: 1-cyclohexanol-a-butyric acid; a-(1-hydroxycyclohexyl)butyric acid; 1-hydroxy-a-ethylcyclohexylacetic acid
Molecular Formula: C10H18O3
Molecular Weight: 186.25
Percent Composition: C 64.49%, H 9.74%, O 25.77%
Literature References: Prepd by hydrolysis of the ethyl ester obtained by the Reformatski reaction: Kon, Naravanan, J. Chem. Soc. 1927, 1536; Kandiah, Linstead, ibid. 1929, 2150; J. G. Maillard et al., Bull. Soc. Chim. Fr. 1958, 244; eidem, DE 1094254; eidem, US 3065134 (1959, 1962 to Lab. Jacques Logeais). Activity studies: Roquet, Jousse, Arch. Int. Pharmacodyn. 125, 172 (1960).
Properties: Colorless crystals from ether-petr ether, mp 81-82°. Formerly reported as viscous oil. d418.8 1.0010. bp24 164°; bp16 167-170°; nD18.8 1.4680 (Kon, Naravanan, loc. cit.). Slightly sol in water, petr ether. Very sol in alcohols, acetone, dioxane, chloroform, ether. Completely sol in aq alkalies at pH 7.5-8.
Melting point: mp 81-82°
Boiling point: bp24 164°; bp16 167-170°
Index of refraction: nD18.8 1.4680 (Kon, Naravanan, loc. cit.)
Density: d418.8 1.0010
Derivative Type: Sodium salt
CAS Registry Number: 1130-23-0
Trademarks: Bilimix (Gero); Bis-Bil (Isola-Ibi); Colepan (Panther-Osfa); Dimene; Epa-Bon (Sierochimica); Hebucol; Maricolene; Tachicol (Radiumfarma); Tri-Bil (Biologici); Tribilina (Drumond)
Molecular Formula: C10H17NaO3
Molecular Weight: 208.23
Percent Composition: C 57.68%, H 8.23%, Na 11.04%, O 23.05%
Properties: White crystalline, slightly hygroscopic powder, mp 299-300°.
Melting point: mp 299-300°
Therap-Cat: Choleretic.
Keywords: Choleretic.

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