Structural Formula Vector Image
Title: Cloranolol
CAS Registry Number: 39563-28-5
CAS Name: 1-(2,5-Dichlorophenoxy)-3-[(1,1-dimethylethyl)amino]-2-propanol
Additional Names: 1-(tert-butylamino)-3-(2,5-dichlorophenoxy)-2-propanol
Molecular Formula: C13H19Cl2NO2
Molecular Weight: 292.20
Percent Composition: C 53.44%, H 6.55%, Cl 24.27%, N 4.79%, O 10.95%
Literature References: b-Adrenergic blocker. Prepn: G. Richter, DE 2213044 (1972 to Res. Inst. Pharm. Chem. Hungary), C.A. 78, 15780p (1973). Effect on plasma renin and blood pressure: I. Tenyi, Curr. Ther. Res. 21, 823 (1977). Pharmacology: M. I. K. Fekete et al., Arch. Int. Pharmacodyn. 248, 190 (1980). Electrophysiological characteristics: F. Solti, E. Czako, Int. J. Clin. Pharmacol. Ther. Toxicol. 18, 229 (1980). Clinical-pharmacological evaluation: E. Török et al., ibid. 200. GC-MS determn in plasma: E. Tomori, E. Elekes, J. Chromatogr. 204, 355 (1981). Multicenter clinical trial: E. Török et al., Int. J. Clin. Pharmacol. Ther. Toxicol. 23, 650 (1985).
Properties: Crystals, mp 82-83°.
Melting point: mp 82-83°
Derivative Type: Hydrochloride
CAS Registry Number: 54247-25-5
Manufacturers' Codes: GYKI-41099
Trademarks: Tobanum (Gedeon Richter)
Molecular Formula: C13H19Cl2NO2.HCl
Molecular Weight: 328.66
Percent Composition: C 47.51%, H 6.13%, Cl 32.36%, N 4.26%, O 9.74%
Properties: Crystals, mp 210-212°.
Melting point: mp 210-212°
Therap-Cat: Antiarrhythmic.
Keywords: ?Adrenergic Blocker; Antiarrhythmic.

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